saralasin Pharm.
(səˈræləsɪn)
[Contraction of 1-sar-8-ala- angiotensin, f. sarcosine + alanine + angioten)sin (f. angio- + hypertensin).]
A synthetic octapeptide which blocks the pressor action of hypertensin II, thereby reducing high blood pressures.
| 1974 Lancet 28 Dec. 1535/1 Angiotensin-II blockade by the competitive antagonist sar1-ala8-angiotensin 11 (‘Saralasin’)... Blockade of angiotensin II with saralasin has been advocated. 1977 Ibid. 24/31 Dec. 1317/1 Two types of renin-angiotensin inhibitor have been tested in renal hypertension—competitive antagonists of angiotensin II, such as saralasin, and inhibitors of the converting enzyme. |