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sarcosine
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sarcosine
sarcosine Chem. (ˈsɑːkəsɪn) Also sarkosin(e, sarcosin. [a. G. sarkosin (Liebig 1847), irreg. f. Gr. σαρκ-, σάρξ flesh + -ine.] A nitrogenous substance, one of the constituents of creatine; methyl glycocoll.1848 Chem. Gaz. VI. 4 Sarcosine. This substance is obtained by boiling a saturated solution of...
Oxford English Dictionary
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Sarcosine
Sarcosine is sweet to the taste.
Biochemistry
Sarcosine is an intermediate and byproduct in glycine synthesis and degradation. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-N-methyl transferase generates sarcosine from glycine.
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Sarcosine dehydrogenase
Function
Sarcosine dehydrogenase is one of the enzymes in sarcosine metabolism, which catalyzes the demethylation of sarcosine to make glycine. Even so, the biological significance of sarcosine dehydrogenase beyond sarcosine metabolism is not entirely known.
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saralasin
saralasin Pharm. (səˈræləsɪn) [Contraction of 1-sar-8-ala- angiotensin, f. sarcosine + alanine + angioten)sin (f. angio- + hypertensin).] A synthetic octapeptide which blocks the pressor action of hypertensin II, thereby reducing high blood pressures.1974 Lancet 28 Dec. 1535/1 Angiotensin-II blockad...
Oxford English Dictionary
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Sarcosine oxidase
Sarcosine oxidase is an enzyme () that catalyzes the oxidative demethylation of sarcosine to yield glycine, H2O2, 5,10-CH2-tetrahydrofolate in a reaction Corynebacterial sarcosine oxidase is a heterotetramer and is produced as an inducible enzyme when Corynebacterium sp.is grown with sarcosine as source
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Sarcosine reductase
In enzymology, a sarcosine reductase () is an enzyme that catalyzes the chemical reaction
acetyl phosphate + methylamine + thioredoxin disulfide N-methylglycine
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SARDH
Sarcosine dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the SARDH gene.
References
Further reading
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Sarcosine/dimethylglycine N-methyltransferase
Sarcosine/dimethylglycine N-methyltransferase (, ApDMT, sarcosine-dimethylglycine methyltransferase, SDMT, sarcosine dimethylglycine N-methyltransferase This enzyme catalyses the following chemical reaction
2 S-adenosyl-L-methionine + sarcosine 2 S-adenosyl-L-homocysteine + betaine (overall reaction)
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Sarcosinemia
, also called hypersarcosinemia and SARDH deficiency, is a rare autosomal recessive metabolic disorder characterized by an increased concentration of sarcosine It can result from an inborn error of sarcosine metabolism, or from severe folate deficiency related to the folate requirement for the conversion of sarcosine
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Glycine/sarcosine N-methyltransferase
Glycine/sarcosine N-methyltransferase (, ApGSMT, glycine-sarcosine methyltransferase, GSMT, GMT, glycine sarcosine N-methyltransferase, S-adenosyl-L-methionine :sarcosine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine) N-methyltransferase (sarcosine(or N,N-dimethylglycine
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N-Oleoylsarcosine
N-Oleoylsarcosine (Sarkosyl O) is an amphiphilic oleic acid derivative having a sarcosine head group (N-methylglycine) which is used as a water-in-oil N-oleyl sarcosine is only slightly toxic and easily biodegradable.
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Glycine/sarcosine/dimethylglycine N-methyltransferase
Glycine/sarcosine/dimethylglycine N-methyltransferase (, GSDMT, glycine sarcosine dimethylglycine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine or N,N-dimethylglycine) N-methyltransferase (sarcosine(or N,N-dimethylglycine or betaine)-forming).
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Creatinase
In enzymology, a creatinase () is an enzyme that catalyzes the chemical reaction
creatine + H2O sarcosine + urea
Thus, the two substrates of this enzyme are creatine and H2O, whereas its two products are sarcosine and urea.
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N-carbamoylsarcosine amidase
In enzymology, a N-carbamoylsarcosine amidase () is an enzyme that catalyzes the chemical reaction
N-carbamoylsarcosine + H2O sarcosine + CO2 + NH3 Thus, the two substrates of this enzyme are N-carbamoylsarcosine and H2O, whereas its 3 products are sarcosine, CO2, and NH3.
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Glycine N-methyltransferase
enzymology, a glycine N-methyltransferase () is an enzyme that catalyzes the chemical reaction
S-adenosyl-L-methionine + glycine S-adenosyl-L-homocysteine + sarcosine Thus, the substrates of this enzyme are S-adenosyl methionine and glycine, whereas its two products are S-adenosylhomocysteine and sarcosine.
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