hydroxamic, a. Chem.
(haɪdrɒkˈsæmɪk)
[tr. G. hydroxamsäure hydroxamic acid (H. Lossen 1869, in Ann. d. Chem. u. Pharm. CL. 315), f. hydrox(ylamin hydroxylamine + am(id amide: see -ic.]
hydroxamic acid: any of the acyl derivatives, R·CO· NHOH or (R·CO)2NHOH, of hydroxylamine (see quot. 1966).
| 1875 Jrnl. Chem. Soc. XXVIII. 751 (heading) Distillation of hydroxamic acids. Ibid. 766 The ethers of aromatic hydroxamic acids. 1926 Biochem. Jrnl. XX. 1362 The hydroxy-acids present in rape oil give hydroxamic acids whose sodium salts are soluble in alcohol. 1966 Millar & Springall Sidgwick's Org. Chem. Nitrogen (ed. 3) ix. 333 The mono N-acyl derivatives of hydroxylamine are usually referred to as hydroxamic acids, a name which strictly refers to structure (I). They can clearly have the alternative structure (II) which should be called a hydroximic acid. In no case are the two isomers known as separate compounds: (I) R·C{b2}O{bbc1}NHOH (II) R·COH{bbc2}NOH and a compound of this class..can react as if it had either structure. Commonly the term hydroxamic is used to imply either of these structures. |