dideoxyinosine, n. Pharm.
(ˌdaɪdiːɒksɪˈɪnəʊsiːn)
[f. di-2 + deoxy- + *inosine n.]
Any of several isomeric purine nucleoside analogues which inhibit the replication of certain viruses; spec. (in full 2{p},3{p}-dideoxyinosine), one which has been used in the treatment of HIV infection.
| 1975 Cancer Res. XXXV. 1548/1, 2{p},3{p}-Dideoxyinosine had absorbance maxima at 248nm (pH 2) and 254nm (pH 12). 1980 Biochemistry XIX. 105/1 Similar substrate activation occurred at high concentrations of the sugar-modified analogues 5{p}-deoxy- and 2{p},5{p}-dideoxyinosine. 1989 New England Jrnl. Med. 23 Nov. 1478/1 Dideoxyinosine should be considered for development as an alternative to AZT in patients with impaired hematopoiesis. 1990 New Scientist 26 May 32 The start of Britain's trials of the AIDS drug dideoxyinosine (DDI) this week comes shortly after the publication..of initial studies on the drug's safety. 1992 Boston Globe 26 July 6/3 Some newly approved drugs like dideoxyinosine, or DDI, work better in combination with the original standby, zidovudine, or AZT. |