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pentamidine
pentamidine Pharm. (pɛnˈtæmɪdiːn) [f. pentane + amidine (f. amide + -ine5).] A diamidine that is used, usu. in the form of its isethionate (a white, hygroscopic, crystalline solid), for the prevention and treatment of certain tropical diseases, esp. sleeping sickness; 1,5-di(4-amidinophenoxy)pentane...
Oxford English Dictionary
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Pentamidine
Pentamidine is in the aromatic diamidine family of medications. History
Pentamidine was first used to treat African trypanosomiasis in 1937 and leishmaniasis in 1940 before it was registered as pentamidine mesylate
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Activities of pentamidine analogs against experimentally induced C ...
Download Table | Activities of pentamidine analogs against experimentally induced C. parvum infections in Hsd:(ICR)BR Swiss micea from publication: Inhibition of Cryptosporidium parvum in neonatal ...
www.researchgate.net
stilbamidine
stilbamidine Pharm. (stɪlˈbæmɪdiːn) [f. stilbene + amidine (f. amide + -ine5).] A diamidine derivative, (H2N)(HN)C·C6H4·CH:CH·C6H4·C(NH)(NH2), of stilbene which has antiprotozoal properties and has been used, usu. in the form of its isethionate, in the treatment of trypanosomiasis and leishmaniasis....
Oxford English Dictionary
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Pneumocystis pneumonia
Prevention
In immunocompromised people, prophylaxis with co-trimoxazole (trimethoprim/sulfamethoxazole), atovaquone, or regular pentamidine inhalations Pentamidine is less often used, as its major limitation is the high frequency of side effects.
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propamidine
propamidine Pharm. (prəʊˈpæmɪdiːn) [f. propane + amide + -ine5.] A diamidine with bactericidal and fungicidal properties which is used, usu. in the form of its isethionate (a white, hygroscopic powder), in dressing minor wounds or burns; 1,3-di(4-amidinephenoxy)propane, CH2[CH2· O·C6H4.C(NH)(NH2)]2....
Oxford English Dictionary
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Synthalin
Further modifications to the chemical structure led to the diamidine class of drugs, of which pentamidine is still used against trypanosomiasis. Pentamidine is also effective against a range of protozoa such as Pneumocystis jirovecii, which causes pneumocystis pneumonia in AIDS patients.
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Lexitropsin
See also
Hoechst 33258
Pentamidine
DNA binding ligand
Single-strand binding protein
Comparison of nucleic acid simulation software
References
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Netropsin
See also
Lexitropsin
Hoechst 33258
DAPI
Pentamidine
DNA-binding protein
Single-strand binding protein
Comparison of nucleic acid simulation software
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Granulomatous amoebic encephalitis
However some survivors have been reported:
Two patients survived after being successfully treated with a therapy consisting of flucytosine, pentamidine The man had been given a recommended drug therapy (pentamidine, sulfadiazine, azithromycin/clarithromycin, fluconazole, flucytosine, and miltefosine) but
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Sappinia amoebic encephalitis
It has been treated with azithromycin, pentamidine, itraconazole, and flucytosine.
References
Encephalitis
Protozoal diseases
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S100P
The interactions between S100P and RAGE are disrupted by cromolyn and pentamidine.
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Trypanocidal agent
DAPI
diminazene
diminazene aceturate
eflornithine
ethidium
isometamidium chloride
lonidamine
melaminylthioarsenate
melarsoprol
nifurtimox
pentamidine
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Isethionic acid
Isethionic acid is also used as a counter ion in certain pharmaceutical formulations, including the antimicrobials hexamidine and pentamidine.
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黑热病的治疗措施是什么?
抗锑病人采用戊脘脒(pentamidine)、二脒替(stilbamidine)、羟眯替(hydroxystilbamidine isothionate)。经多种药物治疗无效而脾高度肿大且有脾功能亢进者,可考虑脾切除。
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