sulphanilamide Pharm.
(sʌlfəˈnɪləmaɪd)
Also (U.S.) sulf-.
[f. sulphanilic s.v. sulph- (f. aniline + -ic) + amide.]
a. The amide of sulphanilic acid, which has wide bacteriostatic activity, has been used, esp. topically, in the treatment of infections due to hæmolytic streptococci, and is the parent compound of the sulphonamides; p-aminobenzenesulphonamide, H2N·C6H4·SO2·NH2.
| 1937 Jrnl. Amer. Med. Assoc. 17 Apr. 1340/2 The Council [on Pharmacy and Chemistry] has therefore formally adopted the nonproprietary name ‘Sulfanilamide’ for para-aminobenzenesulfonamide. 1942 Times 9 Oct. 2/4 A further long list of requirements was sent back from Moscow... The articles dispatched..have included:—530,000 blankets,..10,000 kilos sulphanilamide. 1953 M. Lowry Let. 31 Oct. (1967) 345 The chief engineer has an ulcerated throat, and the ship itself is running on sulfanilamide. 1962 J. Heller Catch-22 xli. 428 Snowden..shifted the position of his hips a bit so that Yossarian could begin salting the wound with sulfanilamide. 1967 Martindale's Extra Pharmacopoeia (ed. 25) 1376/1 Sulfphanilamide,..together with the earlier derivatives, sulphapyridine and sulphathiazole, has been largely superseded by more effective and less toxic compounds. 1974 R. M. Kirk et al. Surgery ii. 27 Sulphanilamide powder is sometimes used topically on raw surfaces, in abscess cavities and body spaces such as the peritoneal and pleural cavities. |
b. Any substituted derivative of this compound.
| 1961 in Webster. 1962 H. A. Krebs in A. Pirie Lens Metabolism Rel. Cataract 351 The effects..of sulphanilamides on the metabolism of p-aminobenzoic acid. |