leucovorin Biochem.
(l(j)uːˈkɒvərɪn)
[f. mod.L. Leuco(nostoc (f. Gr. λευκο- leuco- + nostoc), the generic name + citro)vor(um (f. citr-, citro- + L. vor-āre to devour + -um) the specific epithet, of the bacterium whose growth it was originally found to promote: see -in1.]
= folinic acid.
| 1951 H. P. Broquist et al. in Federation Proc. X. 167/1 A crystalline substance with the properties of the ‘citrovorum factor’ (CF) was prepared from pteroylglutamic acid... The amounts of this crystalline substance, ‘leucovorin’, required for half-maximum growth per ml. of PGA-deficient medium were 0·00015 µg. for Leuconostoc citrovorum 8081. 1954 Poultry Sci. XXXIII. 111/1 Leucovorin (synthetic citrovorum factor) appeared to be inferior to folacin in the nutrition of the chick. 1966 [see folinic a.]. 1971 Cancer XXVIII. 899/1 The combination of methotrexate with Leucovorin rescue is a well-tolerated therapeutic maneuver. |