l-dopa Chem. and Biochem.
(ɛlˈdəʊpə)
Also l- (now rare), L-, -DOPA.
[f. L 7 c + dopa.]
= levodopa.
| 1939 Jrnl. Physiol. XCVI. 51 P Tyrosine given in the diet is partly excreted as l-dopa. 1942 Ibid. CI. 345 In tyrosinosis l(-)-dopa was found to be excreted in the urine after oral administration of l(-)-tyrosine. 1958 Brit. Jrnl. Pharmacol. XIII. 92/1 (heading) Effect of l-dopa and epinine. 1969 3rd Symposium Parkinson's Dis. (R. Coll. Surg. Edin.) 178 L-Dihydroxyphenylalanine (L-dopa) proved far less toxic and more effective than the racemic compound studied earlier. 1970 Passmore & Robson Compan. Med. Stud. II. v. 61/2 [In Parkinsonism] DOPA is given by mouth in doses up to 16 g/day of the racemic mixture or up to 8 g of l-DOPA. 1970 D. B. Calne Parkinsonism x. 94 Disappointing results arise from unwanted effects of l-dopa, such as dyskinesia or psychiatric disturbances. 1970 Times 29 Apr. 2/3 l-Dopa, the drug used experimentally in treatment of Parkinson's Disease, has passed the clinical trial stage. |