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levodopa

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levodopa
levodopa Chem. and Biochem. (ˌliːvəʊˈdəʊpə) Also lævo- (rare). [f. lævo-, levo- + dopa.] The lævorotatory l form of dopa (see L 7 c and dopa).1970 Brit. Med. Jrnl. 7 Feb. 331 (heading) Treatment of Parkinsonism with laevo-dopa. 1970 Jrnl. Amer. Med. Assoc. 16 Mar. 1857/3 Levodopa increased the sever... Oxford English Dictionary
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Levodopa/benserazide
Levodopa/benserazide, sold under the brand name Prolopa among others, is a fixed-dose combination medication used for the treatment of Parkinson's disease Medical uses Levodopa/benserazide is indicated for the treatment of Parkinson's disease with the exception of drug-induced parkinsonism. wikipedia.org
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Carbidopa/levodopa
Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa. Carbidopa prevents the breakdown of levodopa outside the brain. In the brain, levodopa is broken down into dopamine, its active form. wikipedia.org
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lævodopa
lævodopa var. levodopa. Oxford English Dictionary
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Levodopa-induced dyskinesia
Levodopa-induced dyskinesia (LID) is a form of dyskinesia associated with levodopa (l-DOPA), used to treat Parkinson's disease. decrease the induction of dorsal striatal ΔFosB expression in rats when co-administered with levodopa. wikipedia.org
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Melevodopa
It is the methyl ester of levodopa. It is used in tablet form as an effervescent prodrug with 250 times the water solubility of tablet levodopa. wikipedia.org
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Why can't dopamine cross the blood brain barrier but l-dopa can? Levodopa can cross the BBB and is less lipid soluble then dopamine, so dopamine should be able to cross the BBB more easily then l-dopa, but for some re...
Both L-Dopa and Dopamine are polar molecules and thus hydrophilic. They are solvable in water but not in lipids, so they are not able to cross the Blood-brain barrier on their own. The difference is that L-Dopa has a transport protein (SLC7A5) that allows it to pass through the Blood-brain barrier, ...
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Entacapone
Entacapone together with levodopa and carbidopa allows levodopa to have a longer effect in the brain and reduces Parkinson's disease signs and symptoms levodopa, carbidopa, and entacapone. wikipedia.org
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Befiradol
Befiradol (F-13,640; NLX-112) is an experimental drug being studied for the treatment of levodopa-induced dyskinesia. Neurolixis announced that it intended to re-purpose befiradol for the treatment of levodopa-induced dyskinesia in Parkinson's disease. wikipedia.org
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Dopaminergic agents 拟多巴胺药levodopa, (L
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Broadband Terahertz Spectroscopy of Levodopa | Semantic Scholar
DOI: 10.3788/cjl201946.0614017 Corpus ID: 239103440; Broadband Terahertz Spectroscopy of Levodopa @article{ZhongjieZhu2019BroadbandTS, title={Broadband Terahertz Spectroscopy of Levodopa}, author={朱中杰 Zhongjie Zhu and 任冠华 Guanhua Ren and 成超 Chao Cheng and 吴志鹏 Zhipeng Wu and 张建兵 Jianbing Zhang and 韩家广 Jiaguang Han and 赵红卫 Hongwei Zhao}, journal={Chinese ...
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Carbidopa/levodopa/entacapone
, levodopa, and entacapone for the treatment of Parkinson's disease. Levodopa, also a component of carbidopa/levodopa/entacapone, in combination with MAO inhibitors may result in hypertensive reactions. wikipedia.org
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恩他卡朋
Entacapone合并levodopa/dopadecarboxylase时通常须调整levodopa剂量，尤其当levodopa剂量≥800mg或是病人有中度至重度dyskinesias症状出现时，levodopa每日可调降25%的剂量。 因这些副作用主要来自于levodopa，COMT抑制剂只是使levodopa的作用时间延长。 wikipedia.org
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Carbidopa
Used in tandem with L-DOPA (also known as levodopa, a dopamine precursor converted in the body to dopamine), it increases the plasma half-life of levodopa Carbidopa reduces the amount of levodopa required to produce a given response by about 75% and, when administered with levodopa, increases both plasma wikipedia.org
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79岁男性帕金森10年DBS手术治疗可以维持，开始时间2004；服用Carbidopa-levodopa 25/100 从4片每天4小时一片逐渐加到10片/天；同时未服用其他药物最初胳膊刷牙困难，肢体僵硬。
一般来讲，对早期的帕金森氏病患者应首先采取药物治疗，药物治疗3～5年后效果减退，出现了“开、关” 波动现象，异动症和“剂末”恶化效应，病情会变得更加难以控制，这时候就应考虑外科治疗了。
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