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xanthine
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xanthine
xanthine Chem. (ˈzænθaɪn) Also -in. [ad. F. xanthine, f. Gr. ξανθός yellow: see -ine5.] 1. a. A substance (C5H4N4O2) allied to uric acid, found in various organs and secretions of the animal body; originally called xanthic oxide (see xanthic 1 a), from its forming a lemon-yellow compound with nitric...
Oxford English Dictionary
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Xanthine
Xanthine is subsequently converted to uric acid by the action of the xanthine oxidase enzyme. Pathology
People with rare genetic disorders, specifically xanthinuria and Lesch–Nyhan syndrome, lack sufficient xanthine oxidase and cannot convert xanthine
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Xanthine oxidase inhibitor
A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for
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en.wikipedia.org
is Xanthosine Xanthine plus ribose? I'm so confused. I used to think Xanthosine is Xanthine with a ribose instead of H but it appears to me as if it isn't. If you look at the picture in top-right of its wikipedia page...
Technically they are called 7H-xanthine and 9H-xanthine, respectively (thanks to gilleain for the links).
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Xanthinuria
Xanthinuria, also known as xanthine oxidase deficiency, is a rare genetic disorder causing the accumulation of xanthine. Causes
Type I xanthinuria can be caused by a deficiency of xanthine oxidase, which is an enzyme necessary for converting xanthine to uric acid.
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Hypoxanthine
Reactions
It is one of the products of the action of xanthine oxidase on xanthine. However, more frequently in purine degradation, xanthine is formed from oxidation of hypoxanthine by xanthine oxidoreductase.
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Xanthine oxidase
Xanthine oxidase (XO, sometimes XAO) is a form of xanthine oxidoreductase, a type of enzyme that generates reactive oxygen species. Reaction
The following chemical reactions are catalyzed by xanthine oxidase:
hypoxanthine + H2O + O2 xanthine + H2O2
xanthine + H2O + O2 uric acid
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Xanthine phosphoribosyltransferase
and xanthine. , phospho-D-ribosyltransferase, 9-(5-phospho-beta-D-ribosyl)xanthine:diphosphate, and 5-phospho-alpha-D-ribosyltransferase.
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en.wikipedia.org
WO2021109970A1 - Xanthine derivative pharmaceutical composition and ...
the test of the influencing factors of the present invention shows that after being placed under high humidity (RH92.5%) conditions for 10 days, the properties, dissolution, related substances and content of the composition samples prepared in the examples of the present invention have no significant changes; After being placed under the conditions of °C and light (4500Lx ⁇ 500Lx) for 10 ...
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Xanthine dehydrogenase
Xanthine dehydrogenase catalyzes the following chemical reaction:
xanthine + NAD+ + H2O urate + NADH + H+
The three substrates of this enzyme are xanthine Other names in common use include NAD+-xanthine dehydrogenase, xanthine-NAD+ oxidoreductase, xanthine/NAD+ oxidoreductase, and xanthine oxidoreductase.
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8-Phenyltheophylline
the adenosine receptors A1 and A2A, but unlike other xanthine derivatives has virtually no activity as a phosphodiesterase inhibitor. See also
8-Chlorotheophylline
8-Cyclopentyltheophylline
DPCPX
DMPX
Xanthine
References
Adenosine receptor antagonists
Xanthines
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en.wikipedia.org
8-Chlorotheophylline
8-Chlorotheophylline, also known as 1,3-dimethyl-8-chloroxanthine, is a stimulant drug of the xanthine chemical class, with physiological effects similar Despite being classified as a xanthine stimulant, 8-chlorotheophylline can generally not produce any locomotor activity above control in mice and does
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en.wikipedia.org
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
Xanthine dehydrogenase () catalyzes the hydrogenation of xanthine to urate, and also requires FAD, molybdenum and two 2FE-2S clusters as cofactors. This activity is often found in a bifunctional enzyme with xanthine oxidase () activity too.
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en.wikipedia.org
Diprophylline
Diprophylline (INN) or dyphylline (USAN) (trade names Dilor, Lufyllin), is a xanthine derivative with bronchodilator and vasodilator effects. See also
Xanthine
References
Adenosine receptor antagonists
Diols
Phosphodiesterase inhibitors
Xanthines
wikipedia.org
en.wikipedia.org
Oxipurinol
By inhibiting xanthine oxidase, it reduces uric acid production. References
Pyrazolopyrimidines
Xanthine oxidase inhibitors
Human drug metabolites
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en.wikipedia.org