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thrombin

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Thrombin: Uses, Interactions, Mechanism of Action | DrugBank Online
Also known as coagulation factor II, thrombin is a serine protease that plays a physiological role in regulating hemostasis and maintaining blood coagulation . Once converted from prothrombin, thrombin converts fibrinogen to fibrin, which, in combination with platelets from the blood, forms a clot. go.drugbank.com
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Thrombin - Wikipedia
Prothrombin (Coagulation factor II) is encoded in the human by the F2 gene. It is proteolytically cleaved during the clotting process by the prothrombinase ... en.wikipedia.org
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Thrombin - StatPearls - NCBI Bookshelf
Thrombin is a topical hemostatic agent used to control and minimize blood loss during surgical procedures, is utilized in conjunction or as an alternative to ... www.ncbi.nlm.nih.gov
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thrombin
thrombin Physiol. Chem. (ˈθrɒmbɪn) [mod. f. as prec. + -in.] The substance which by interaction with fibrinogen gives rise to fibrin, and is hence the immediate cause of the clotting of shed blood; fibrin-ferment.1898 E. A. Schäfer's Text-bk. Physiol. I. 160 Fibrin-ferment (thrombin) or its precurso... Oxford English Dictionary
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Thrombin - an overview | ScienceDirect Topics
Thrombin is an endogenous protein involved in the coagulation cascade, where it has a key role in the formation of fibrin clots by converting fibrinogen to ... www.sciencedirect.com
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Multifunctional roles of thrombin - PubMed
Thrombin is an unique molecule that functions both as a procoagulant and anticoagulant. In its procoagulant role it activates platelets through its receptor on ... pubmed.ncbi.nlm.nih.gov
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The role of thrombin in haemostasis - Blood Coagulation & Fibrinolysis
Thrombin is a multifunctional serine protease generated in injured cells. The generation of thrombin in coagulation plays a central role in the functioning of ... journals.lww.com
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Molecule of the Month: Thrombin - PDB-101
Thrombin is a serine protease: a protein-cutting enzyme that uses a serine amino acid to perform the cleavage. pdb101.rcsb.org
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Thrombin - an overview | ScienceDirect Topics
Thrombin, one of the key proteins in the coagulation cascade, is a serine protease that initiates the physiological formation of fibrin clots and platelet ... www.sciencedirect.com
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The Dynamics of Thrombin Formation - AHA Journals
This is a highly regulated, dynamic process in which thrombin itself plays many roles, positively and negatively its production and destruction. www.ahajournals.org
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understanding the structural basis of thrombin formation and function
Thrombin is the principal clotting factor and maintains the balance between bleeding and thrombosis. It is at the centre of a complex series of molecular events ... www.bhf.org.uk
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Thrombin–antithrombin complex
Thrombin–antithrombin complex (TAT) is a protein complex of thrombin and antithrombin. It is a marker of net activation of coagulation. Since thrombin is rapidly bound by antithrombin, TAT is a useful measure for thrombin level in the blood. wikipedia.org
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Thrombin-activatable fibrinolysis inhibitor
Term thrombin-activatable fibrinolysis inhibitor may refer to: Carboxypeptidase B2, an enzyme that in humans is encoded by the CPB2 gene Lysine carboxypeptidase wikipedia.org
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What stops the coagulation process? Whenever there are minor/major injury to blood vessels, the platelets, fibrin, thrombin, etc. are recruited. They then seal the wound and block bleeding. What tells them that their...
Exposed collagen at the site of vessel damage simultaneously initiates plates aggregation and the clotting cascade. So, when the wound is sealed and no more collagen is exposed, which is the main factor to activate the cascade, the blood clothing cascade stops.
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Hirudin
The principal inhibitor of thrombin in normal blood circulation is antithrombin. Hirudin is the most potent natural inhibitor of thrombin. wikipedia.org
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