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thrombin

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thrombin
thrombin Physiol. Chem. (ˈθrɒmbɪn) [mod. f. as prec. + -in.] The substance which by interaction with fibrinogen gives rise to fibrin, and is hence the immediate cause of the clotting of shed blood; fibrin-ferment.1898 E. A. Schäfer's Text-bk. Physiol. I. 160 Fibrin-ferment (thrombin) or its precurso... Oxford English Dictionary
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Thrombin
, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. for Human Thrombin. wikipedia.org
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Thrombin–antithrombin complex
Thrombin–antithrombin complex (TAT) is a protein complex of thrombin and antithrombin. It is a marker of net activation of coagulation. Since thrombin is rapidly bound by antithrombin, TAT is a useful measure for thrombin level in the blood. wikipedia.org
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Thrombin-activatable fibrinolysis inhibitor
Term thrombin-activatable fibrinolysis inhibitor may refer to: Carboxypeptidase B2, an enzyme that in humans is encoded by the CPB2 gene Lysine carboxypeptidase wikipedia.org
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What stops the coagulation process? Whenever there are minor/major injury to blood vessels, the platelets, fibrin, thrombin, etc. are recruited. They then seal the wound and block bleeding. What tells them that their...
Exposed collagen at the site of vessel damage simultaneously initiates plates aggregation and the clotting cascade. So, when the wound is sealed and no more collagen is exposed, which is the main factor to activate the cascade, the blood clothing cascade stops.
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Hirudin
The principal inhibitor of thrombin in normal blood circulation is antithrombin. Hirudin is the most potent natural inhibitor of thrombin. wikipedia.org
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fibrinogens and fibrins - are they the same molecule? Some proteins are "activated", like fibrinogens; they are turned into fibrins by thrombins, and then the fibrins can aid in blood clotting. Are fibrinogens and fi...
You could say they are the same molecule, but a molecule whose function is to change its state and properties very quickly when activated by thrombin. Thrombin is an enzyme called a protease which very specifically cuts the ends off of two of those protein chains.
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Thrombin receptor
There are species-specific differences in thrombin receptor expression in platelets and other cell types, in which differences in thrombin concentrations As seen in human platelets, PAR1 and PAR4 are the functional thrombin receptors, whereas PAR3 and PAR4 are functional thrombin receptors in mouse platelets wikipedia.org
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Thrombin time
Batroxobin has a similar action to thrombin but unlike thrombin it is not inhibited by heparin. The time between the addition of the thrombin and the clot formation is recorded as the thrombin clotting time. wikipedia.org
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Bovine Thrombin牛凝血|酶_蛋白酶-翌圣生物科技（上海）股份有限公司
Mar 1, 2023Bovine Thrombin牛凝血|酶. Bovine Thrombin牛凝血|酶是从牛的血浆纯化制得，具有纯度高、比活高、不含有其他蛋白酶活性、灭活病毒、生产稳定性好等特点。. 该酶最适切割位点：A-B-Pro-Arg- -X-Y （其中，A和B为疏水氨基酸，X和Y为非酸性氨基酸），常见的识别序列为：1 ...
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凝血酶（Thrombin）和凝血酶原（Prothrombin）的区别与联系? - 知乎
定义上，凝血酶是血浆中的一种酶，通过将纤维蛋白原转化为纤维蛋白来引起血液凝固。 相反，凝血酶原是指存在于血浆中的一种蛋白质，在凝血过程中转化为活性凝血酶。 结构上，凝血酶包含两条由 36 个（A 链）和 259 个（B 链）残基组成的多肽链，它们通过残基 C1 和 C122 之间的二硫键共价连接，而凝血酶原是一种模块化组装体，包括 N 端 Gla 结构域（残基 1-46）、kringle-1（残基 65-143）、kringle-2（残基 170-248）和 C 端蛋白酶结构域（残基 285-579）。 凝血酶是通过激活凝血酶原产生的，而凝血酶原是在肝脏中合成的。 凝血酶的分子量为 37 kDa，而凝血酶原的分子量为 72 kDa。 凝血酶不太复杂，而凝血酶原更复杂。
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Thrombin generation assay
all generated thrombin has been inhibited) Peak height or peak thrombin (molar concentration (e.g., nM) of thrombin; peak or maximum concentration of thrombin generated) Velocity index (slope of thrombin generation between lag time/first thrombin generation and time to peak; corresponds to first derivative wikipedia.org
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Direct thrombin inhibitor
Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin Dabigatran is an oral direct thrombin inhibitor. wikipedia.org
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Thrombomodulin
complex with thrombin. Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor wikipedia.org
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Prothrombinase
Thrombin activates Factor V by cleaving off the B domain. Other proteases also activate Factor V, but this cleavage is primarily carried out by thrombin. wikipedia.org
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