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protide

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protide
protide Biochem. (ˈprəʊtaɪd) Also -id (-ɪd). [a. F. protide (G. Bertrand 1923, in Bull. de la Soc. de Chim. biol. V. 102), f. protéine protein: see -ide.] A generic term for a protein, peptide, or amino-acid. Hence proˈtidic a. The scheme of nomenclature proposed by Bertrand met with little favour a... Oxford English Dictionary
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Protide
The ProTide technology is a prodrug approach used in molecular biology and drug design. Remdesivir, the only anti-viral FDA-approved to treat COVID-19 also uses the ProTide prodrug technology (self-immolation is the key principle of ProTide wikipedia.org
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Tenofovir alafenamide
It was developed by Gilead Sciences based on the protide technology of Chris McGuigan for use in the treatment of HIV/AIDS and chronic hepatitis B, and wikipedia.org
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erythro-
erythro- (ɛˈrɪθrəʊ-) (before a vowel eˈrythr-), combining form of Gr. ἐρυθρό-ς red, in several compounds occurring in Chemistry, with a few in Mineralogy, etc. eˈrythro-benˈzene (see quot.). eˈrythroblast [G. (M. Löwit 1886, in Sitzungsber. d. Akad. d. Wissenschaften in Wien 3rd Ser. XCII. 56)], any... Oxford English Dictionary
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Hydride
Appendix on nomenclature Protide, deuteride and tritide are used to describe ions or compounds that contain enriched hydrogen-1, deuterium or tritium, wikipedia.org
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Sofosbuvir
Sofosbuvir is a prodrug of the Protide type, whereby the active phosphorylated nucleotide is granted cell permeability and oral bioavailability. The design of sofosbuvir, based on the ProTide approach, avoids this slow step by building the first phosphate group into the structure of the drug during wikipedia.org
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Remdesivir
Pharmacology Activation Remdesivir is a protide (prodrug of nucleotide) able to diffuse into cells, where it is converted to GS-441524 monophosphate wikipedia.org
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ProTide 技术是什么？
ProTide技术成功地应用于各种核苷类似物。[5][6]特别是，ProTide方法已用于几种经过临床评估的抗HCV核苷类似物，包括2013年FDA批准的化合物索非布韦和2016年FDA批准的化合物Tenofovir alafenamide。 Remdesivir，唯一的抗病毒FDA-批准用于治疗COVID-19还采用了ProTide药技术。 瑞德西韦Remdesivir背后的科学，就是ProTide技术的应用： 雷姆昔韦起核苷酸类似物的作用。核苷酸充当细胞中DNA和RNA的单体/亚基。 zhihu
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Hydrogen ion
Hydrogen anions are formed when additional electrons are acquired: Hydride: general name referring to the negative ion of any hydrogen isotope (H−) Protide wikipedia.org
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ProTide 技术是什么？
它从用简单的烷基掩蔽核苷单磷酸酯和单膦酸酯基团开始，并演变成今天已知的复杂的 ProTide 系统。该技术已广泛应用于药物发现，它已经导致发现了两种 FDA 批准的（抗病毒）ProTides。 ProTides 的初始工作可以追溯到 1980 年代后期。 回顾过去，这一观察结果证明对 ProTide 技术在药物发现方面的成功至关重要，因为所有进入临床试验的 ProTide 和已批准用于临床的 ProTide 都带有l-丙氨酸部分。对不同类型（即α、β 和γ）氨基酸类型的进一步研究表明α-氨基酸的优越性。 zhihu
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