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proteolysis
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proteolysis
‖ proteolysis Phys. Chem. (prəʊtiːˈɒlɪsɪs) [mod.L., f. *prōteo-, assumed combining form of protein + Gr. λύσις a loosening, solution.] A term for a. The separation of the proteins from a protein-containing mixture; b. The splitting up of proteins by ferments. (Syd. Soc. Lex.) Although parallel in fo...
Oxford English Dictionary
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Fast parallel proteolysis
History and background
Proteolysis is widely used in biochemistry and cell biology to probe protein structure. These include Pulse Proteolysis, Proteolytic Scanning Calorimetry and FASTpp.
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The Proteolysis Map
The Proteolysis MAP (PMAP) was an integrated web resource focused on proteases. Its domain now links to a scam/spam browser extender. Goal
Proteolytic pathways, or proteolysis, are the series of events controlled by proteases that occur in response to specific stimuli.
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protease
protease Physiol. Chem. (ˈprəʊtiːeɪs) [f. proteolysis + -ase in diastase; first formed as F. proteinase (G. Malfitano 1900, in Ann. de l'Inst. Pasteur XIV. 420).] A proteolytic enzyme or ferment; a proteinase or peptidase.1903 Ann. Bot. XVII. 237 There is at present evidence that enzymes which diges...
Oxford English Dictionary
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Proteolysis targeting chimera
A proteolysis targeting chimera (PROTAC) is a heterobifunctional molecule composed of two active domains and a linker, capable of removing specific unwanted Rather than acting as a conventional enzyme inhibitor, a PROTAC works by inducing selective intracellular proteolysis.
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en.wikipedia.org
why can proteolysis only occur once on a enzyme? My texbook says that proteolysis can occur once in the lifetime of the enzyme? I know that proteases must cleave the zymogen at more or more specific locations, but why...
Because you mention zymogens, I assume the proteolysis you are referring to is the conversion of the inactive to active form of an enzyme by cleavage.
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Protease
In the absence of functional accelerants, proteolysis would be very slow, taking hundreds of years. peptide to amino acids (unlimited proteolysis).
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Glycogenolysis & Gluconeogenesis Is glycogenolysis and Gluconeogenesis is the same in the terms of product formed? This doubt arrived when I was attempting true & false and the question was _Glucocorticoids stimulat...
Therefore: _Glucocorticoids **do not** stimulate glycogenolysis, lipolysis and proteolysis._
And the answer is _false_.
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凝血酶
database for peptidases and their inhibitors: S01.217
GeneReviews/NCBI/NIH/UW entry on Prothrombin Thrombophilia
Anti-coagulation & proteases by The Proteolysis Map-animation
PMAP: The Proteolysis Map/Thrombin
凝血系统
急性期蛋白
EC 3.4.21
外周膜蛋白
抗出血药
自体抗原
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Generation of a novel proteolysis resistant vascular ... - ResearchGate
Request PDF | Generation of a novel proteolysis resistant vascular endothelial growth factor(165) variant by a site-directed mutation at the plasmin sensitive cleavage site | Vascular endothelial ...
www.researchgate.net
SOBER1
See also
Acylation
Catalytic triad
Compendium of protein lysine acetylation
Enzyme assay
Organic synthesis
Protein dynamics
Proteolysis
The Proteolysis
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Hydroxyaminovaleric acid
It is also produced by reduction of glutamate-5-semialdehyde residues followed by proteolysis.
References
Alpha-Amino acids
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金属蛋白酶
另见
基质金属蛋白酶
The Proteolysis Map
参考文献
外部链接
The MEROPS online database for peptidases and their inhibitors: Metallo Peptidases
Proteopedia: Metalloproteases
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PROTAC药物到底是什么?
PROTAC(proteolysis-targeting chimeras)是一种利用泛素-蛋白酶体系统(Ubiquitin-Proteasome System, UPS)对靶蛋白进行降解的药物开发技术。
zhihu
www.zhihu.com