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porphobilinogen
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porphobilinogen
porphobilinogen Biochem. (ˌpɔːfəʊbaɪˈlɪnəgən) [a. G. porphobilinogen (Waldenström & Vahlquist 1939, in Zeitschr. f. physiol. Chem. CCLX. 191), f. prec.: see -ogen.] A colourless, crystalline, substituted pyrrole, C10H14N2O4 (see quot. 1972), which in animals is a precursor of porphyrins and is excre...
Oxford English Dictionary
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Porphobilinogen
Porphobilinogen (PBG) is an organic compound that occurs in living organisms as an intermediate in the biosynthesis of porphyrins, which include critical to the nitrogen atom) into hydroxymethyl bilane by the enzyme porphobilinogen deaminase, also known as hydroxymethylbilane synthase.
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Porphobilinogen deaminase
Porphobilinogen deaminase is involved in the third step of the heme biosynthetic pathway. :
4 porphobilinogen + H2O hydroxymethylbilane + 4 NH3
Structure and function
Functionally, porphobilinogen deaminase catalyzes the loss of ammonia from
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porphobilin
porphobilin Biochem. (pɔːfəʊˈbaɪlɪn) [a. G. porphobilin (Waldenström & Vahlquist 1939, in Zeitschr. f. physiol. Chem. CCLX. 191), f. porph-yrie porphyria + -o + L. bīl-is bile: see -in1.] Any of a group of red-brown pigments derived from porphobilinogen.1939 Chem. Abstr. XXXIII. 8777/1 Boiling in ac...
Oxford English Dictionary
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Morpheein
The one protein that is established to function as a morpheein is porphobilinogen synthase, though there are suggestions throughout the literature that An inhibitor of porphobilinogen synthase with this mechanism of action has been documented.
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uroporphyrin
uroporphyrin Biochem. (jʊərəʊˈpɔːfɪrɪn) [ad. G. urinporphyrin (H. Fischer 1915, in Zeitschr. f. physiol. Chem. XCV. 34): see uro-1 and porphyrin.] Any of a group of porphyrins, occurring esp. in the urine during certain types of porphyria, in which each of the pyrrole rings has one acetate and one p...
Oxford English Dictionary
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PBG
Ground, a term used in theater lighting to designate an ordinary NEMA 5-15 electrical power connector
The Pepsi Bottling Group (NYSE:PBG), a US company
Porphobilinogen
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Chlorophyll b
The initial steps incorporate glutamic acid into 5-aminolevulinic acid (ALA); two molecules of ALA are then reduced to porphobilinogen (PBG), and four
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isomerase
isomerase Biochem. (aɪˈsɒməreɪz, -s) [f. isomer + -ase.] Any enzyme which brings about an isomerization reaction; orig. applied to two particular enzymes (see quots. 1943, 1944).1943 I. Banga in Stud. Inst. Med. Chem. Univ. Szeged III. 67 When ADP had been incubated with isomerase, the product was s...
Oxford English Dictionary
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Methods for The Identification of Inhibitors of Porphobilinogen ...
methods for the identification of inhibitors of porphobilinogen deaminase, bifunctional purine biosynthetic protein, and a transcription factor as antibiotics
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Phycocyanobilin
Two molecules of 5-ALA undergo a condensation reaction catalyzed by Porphobilinogen (PBG) Synthase to yield a molecule of Porphobilinogen (PBG) (not shown Four molecules of PBG are polymerized into a linear tetrapyrrole by Porphobilinogen deaminase.
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Dihydrosirohydrochlorin
Dihydrosirohydrochlorin is derived from a tetrapyrrolic structural framework created by the enzymes deaminase and cosynthetase which transform aminolevulinic acid via porphobilinogen
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Acute intermittent porphyria
Acute intermittent porphyria (AIP) is a rare metabolic disorder affecting the production of heme resulting from a deficiency of the enzyme porphobilinogen Elevated urine porphobilinogen confirms diagnosis of AIP, hereditary coproporphyria (HCP), or variegate porphyria (VP).
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Hydroxymethylbilane
Metabolism
HMB is generated from four molecules of porphobilinogen by the enzyme porphobilinogen deaminase:
The enzyme uroporphyrinogen III synthase
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C10H14N2O4
{{DISPLAYTITLE:C10H14N2O4}}
The molecular formula C10H14N2O4 (molar mass: 226.23 g/mol, exact mass: 226.0954 u) may refer to:
Carbidopa
2C-N
Porphobilinogen
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