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physostigmine
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physostigmine
physostigmine Chem. and Pharm. (faɪsəʊˈstɪgmiːn) Also † -in. [ad. G. physostigmin (Jobst & Hesse 1864, in Ann. d. Chem. u. Pharm. CXXIX. 118): see Physostigma and -ine5.] A colourless or pale yellow crystalline tricyclic alkaloid, C15H21N3O2, which is the active principle of the calabar bean and is ...
Oxford English Dictionary
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Physostigma venenosum
Toxicology
Calabar bean contains physostigmine, a reversible cholinesterase inhibitor alkaloid. The alkaloid physostigmine acts in effect like nerve gas, influencing communication between the nerves and muscles, and resulting in copious salivation
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Holothurin
on nerves in desheathed bullfrog sciatic nerve and rat phrenic nerve preparations, and its potency can be compared to that of cocaine, procaine, and physostigmine In another experiment on rat phrenic nerve, the nerve-disrupting effect of holothurin A is found to be preventable when specific concentrations of physostigmine
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eserine
eserine Chem. (ˈɛsəraɪn) [a. Fr. ésérine, f. éséré, the native name of the plant; see -ine. (First used in Fr. by Vée Recherches chimiques sur la fève du Calabar 1865).] A crystalline alkaloid obtained from the Calabar bean, the fruit of Physostigma venenosum, employed in solution in medicine to pro...
Oxford English Dictionary
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Cymserine
Cymserine is a drug related to physostigmine, which acts as a reversible cholinesterase inhibitor, with moderate selectivity (15×) for the plasma cholinesterase
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Eseroline
It is a metabolite of the acetylcholinesterase inhibitor physostigmine but unlike physostigmine, the acetylcholinesterase inhibition produced by eseroline
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Stigmine
Examples include:
Distigmine
Neostigmine
Physostigmine
Pyridostigmine
Rivastigmine
Acetylcholinesterase inhibitors
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Procyclidine
A suspected overdose with severe life-threatening symptoms should immediately be brought to medical attention, where reversal can be attempted with physostigmine
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Anticholinergic
Reversible acetylcholinesterase inhibitor agents such as physostigmine can be used as an antidote in life-threatening cases. of tricyclic antidepressant ingestion is generally considered a contraindication to physostigmine administration.
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毒扁豆
毒扁豆的种子含有毒扁豆碱(physostigmine),可使人类窒息死亡。
历史
毒扁豆在奈及利亚卡拉巴普遍生长,故又名卡拉巴豆。
参考文献
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药理 Flashcards | Quizlet
Study with Quizlet and memorize flashcards containing terms like pilocarpine, neostigmine, physostigmine and more.
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Streptomyces pseudogriseolus
Streptomyces pseudogriseolus produces xanthomycin, deseryladenomycin and physostigmine.
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Rostral ventrolateral medulla
Physostigmine, a choline-esterase inhibitor, elevates endogenous levels of acetylcholine and causes a rise in blood pressure by stimulation of the RVLM
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Ludwig Laqueur
Laqueur is remembered for his research of physostigmine, a chemical substance found in the Calabar bean (Physostigma venenosa) of West Africa. In 1876 he published Ueber eine neue therapeutische Verwendung des Physostigmin, suggesting the use of physostigmine for the treatment of glaucoma .
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