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phlorizin

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phlorizin
phlorizin Chem. (flɒˈraɪzɪn, ˈflɒrɪzɪn) Also phlo(r)rhizin, phloˈridzin († -ine), † phloˈridzin(e. [a. G. phloridzin (L. de Koninck 1835, in Ann. der Pharm. XV. 76; phlorrhizin suggested there by the editor as the proper form of the word, f. Gr. ϕλό-ος, ϕλοι-ός bark + ῥίζα root + -in.] A bitter subs... Oxford English Dictionary
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Phlorizin
Phlorizin is a glucoside of phloretin, a dihydrochalcone. A white solid, samples often appear yellow owing to impurities. Upon prolonged exposure to aqueous solutions phlorizin hydrolyzes to phloretin and glucose. wikipedia.org
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Phloretin
Metabolism In rats, ingested phlorizin is converted into phloretin by hydrolytic enzymes in the small intestine. an animal model, phloretin inhibited active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin wikipedia.org
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phloro-
phloro- before a vowel phlor-, used in Chem., to form names of substances connected with phlorizin, as phloramine (ˈflɒrəmaɪn) [amine], the amine (C6H7NO2 = C6H5O2·NH2) obtained in thin shining films by the action of ammonia on phloroglucin (Watts Dict. Chem. IV. 488). phloretin (ˈflɔərɪtɪn), a swee... Oxford English Dictionary
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Lactase-phlorizin hydrolase
Lactase-phlorizin hydrolase may refer to: Phloretin hydrolase, an enzyme Glycosylceramidase, an enzyme wikipedia.org
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phlorizinized
phlorizinized, ppl. a. (flɒˈraɪzɪnaɪzd) Forms: see prec. [f. prec. + -ize + -ed1.] That has been given phlorizin. So phloˈrizinize v. trans.1900 Amer. Jrnl. Physiol. IV. p. x, A well phlorhizinized muscle begins to go into rigor within five minutes after death. 1912 A. E. Taylor Digestion & Metaboli... Oxford English Dictionary
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Glycosylceramidase
Other names in common use include phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin β-glucosidase , lactase-phlorizin hydrolase, and phloridzin glucosidase. wikipedia.org
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Phloretin hydrolase
This enzyme is also called lactase-phlorizin hydrolase. References EC 3.7.1 Enzymes of unknown structure Dihydrochalcones metabolism wikipedia.org
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Glycoside hydrolase family 1
with a number of known activities; beta-glucosidase (); beta-galactosidase (); 6-phospho-beta-galactosidase (); 6-phospho-beta-glucosidase (); lactase-phlorizin wikipedia.org
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C21H24O10
C21H24O10}} The molecular formula C21H24O10 (molar mass: 436.41 g/mol, exact mass: 436.136947 u) may refer to: Nothofagin, a C-linked phloretin glucoside Phlorizin wikipedia.org
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基因本体
[EC:3.2.1.108] synonym: "lactase-phlorizin hydrolase activity" BROAD [EC:3.2.1.108] synonym: "lactose galactohydrolase activity" EXACT [EC:3.2.1.108] wikipedia.org
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Discovery and development of gliflozins
Phlorizin Phlorizin is a compound that has been known for over a century. T-1095 Because Phlorizin is a nonselective inhibitor with poor oral bioavailability, a phlorizin derivative was synthesised and called T-1095. wikipedia.org
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SGLT2 inhibitor
Phlorizin was the first type of gliflozin and it was non-selective against SGLT2/SGLT1. However Phlorizin is very unstable, it is rapidly degraded by glucosidases in the small intestines, so it can not be used as an oral administration medication wikipedia.org
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Sodium/glucose cotransporter 2
See also SGLT Family Discovery and development of gliflozins Phlorizin - a competitive inhibitor of SGLT1 and SGLT2 References Further reading wikipedia.org
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海藻糖酶缺乏的诊断是什么？
人乳糖酶根皮苷水解酶(lactase phlorizin hydrolase)的基因定位于第2号染色体。婴儿的小肠黏膜上皮刷状缘缺乏乳糖酶时，在首次母乳喂饲后即出现水样泻。成年人二糖酶缺乏最常见的是乳糖酶缺乏。乳糖酶活性在新生儿时最高，以后可降低至其最大量的10%，成年人乳糖酶缺乏者正是在这一水平。
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