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pharmacophore
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pharmacophore
pharmacophore, n. Pharmacol. Brit. /ˈfɑːməkəˌfɔː/, U.S. /ˈfɑrməkəˌfɔ(ə)r/ [‹ pharmaco- comb. form + -phore comb. form, after pharmacophoric adj.] The part of a molecule that is responsible for its characteristic pharmacological activity; a pharmacologically active group.1964 Biochem. Pharmacol. 13 3...
Oxford English Dictionary
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Pharmacophore
A pharmacophore model explains how structurally diverse ligands can bind to a common receptor site. A well-defined pharmacophore model includes both hydrophobic volumes and hydrogen bond vectors.
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AncPhore - ddtmlab
AncPhore is a versatile tool for pharmacophore-based drug discovery, which is characterized by pharmacophore feature analysis and anchor pharmacophore steered molecular fitting and virtual screening. It involves eight types of pharmacophore features, including hydrogen bond donor, hydrogen bond acceptor, positively charged center, negatively ...
ancphore.ddtmlab.org
pharmacophoric
pharmacophoric, a. Pharmacol. Brit. /ˌfɑːməkəˈfɒrɪk/, U.S. /ˌfɑrməkəˈfɔrɪk/ [‹ pharmaco- comb. form + -phoric (in e.g. osmophoric adj.). Compare later pharmacophore n. Compare French pharmacophore (1956 or earlier).] Of the nature of, relating to, or involving a pharmacophore.1953F. W. Schueler in A...
Oxford English Dictionary
prophetes.ai
Benocyclidine
BCP was used to try to find a common pharmacophore for DRI type stimulants.
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Metyltetraprole
Binding Mode
The structure of the tetrazolinone pharmacophore is very similar to the triazolone pharmacophore of an inhibitor developed by AgoEva, for
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Ethyl caffeate
Pharmacophore modeling, molecular docking, and molecular dynamics simulation studies also indicate that ethyl caffeate is a potential inhibitor of the
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Clorotepine
Due to its very potent activity at the D2 receptor, along with tefludazine, clorotepine was used as the basis for developing a 3-dimensional (3D) pharmacophore
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Inte:Ligand
more than 1500 literature, book chapters and review articles published related to InteLigand software technology in the areas of virtual screening, 3D-pharmacophore LigandScout Advanced, is a scientific software program that has all of the functionality of LigandScout Essential plus docking, Apo site pharmacophore
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en.wikipedia.org
RH-34
structural modification of the selective 5-HT2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore
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Pyridazine
The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.
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Vinyl sulfone
The sulfone makes the vinyl group electrophilic, allowing it to be used as a pharmacophore for binding to the thiol of cysteine residues.
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Kutlu Ö. Ülgen
Kutlu Özergin Ülgen is a Turkish biochemical engineer researching pharmacophore modelling to identify pharmacological chaperones used to treat infectious Ülgen researches pharmacophore modelling to identify pharmacological chaperones to treat infectious diseases, genetic diseases, and cancer.
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en.wikipedia.org
Salicyl alcohol
Salicyl alcohol appears as a pharmacophore in several notable β2-adrenoceptor agonists (e.g. salbutamol), as well as in synthetic estrone analogs, e.g.
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4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone
vitro pharmacological profile from cocaine at the three transporter sites (dopamine, serotonin, and norepinephrine) was discovered through 3D-database pharmacophore
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