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orotic

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orotic
orotic, a. Chem. (ɒˈrɒtɪk) [ad. It. orotico (Biscaro & Belloni 1905, in Ann. della Soc. Chim. di Milano XI. 18), f. Gr. ὀρό-ς serum, whey + It. -otico -otic.] orotic acid, a colourless crystalline heterocyclic acid, C4HN2(OH)2COOH, which is found in milk and is a growth factor for some micro-organis... Oxford English Dictionary
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Orotic acid
Orotic acid () is a pyrimidinedione and a carboxylic acid. Pathology A buildup of orotic acid can lead to orotic aciduria and acidemia. wikipedia.org
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Orotic aciduria
Orotic aciduria (AKA hereditary orotic aciduria) is a disease caused by an enzyme deficiency, resulting in a decreased ability to synthesize pyrimidines Orotic aciduria is characterized by excessive excretion of orotic acid in urine because of the inability to convert orotic acid to UMP. wikipedia.org
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orotic aciduria
orotic aciduria Path. (ɒˌrɒtɪk æsɪˈdjuːrɪə) Also as one word. [f. orotic acid (see prec.) + -uria.] A rare genetic disorder in which an enzyme deficiency impairs the metabolism of orotic acid, resulting in anæmia and excessive amounts of the acid in the blood and urine. Hence oˌrotic aciˈduric a.195... Oxford English Dictionary
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Magnesium orotate
Magnesium orotate, the magnesium salt of orotic acid, is a mineral supplement. in treating extracellular magnesium deficiency, as well as in mitigating magnesium depletion that inhibits the binding of adenosine triphosphate via orotic wikipedia.org
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uracil
uracil Biochem. (ˈjʊərəsɪl) [a. G. uracil (R. Behrend 1885, in Ann. d. Chemie CCXXIX. 11), of unknown origin (perh. f. Eng. urea + G. ac-etsäure acetic acid + -il).] A pyrimidine base, C4H4N2O2, which is a constituent of RNA.1890 Roscoe & Schorlemmer Treat. Chem. (ed. 2) III. 387 Behrend has succeed... Oxford English Dictionary
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Orotate phosphoribosyltransferase
Orotic acid and PRPP are stabilized in the active site mostly by hydrogen bonding with stabilizing interactions from Lys 26, Phe 34 and Phe 35 to orotic Orotic aciduria was first reported in 1959 when excess orotic acid was found in the urine of an infant. wikipedia.org
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Orotidine
Orotidine is a nucleoside formed by attaching orotic acid to a ribose ring via a β-N1-glycosidic bond. It is found in bacteria, fungi and plants. wikipedia.org
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4,5-Dihydroorotic acid
4,5-Dihydroorotic acid is a derivative of orotic acid which serves as an intermediate in pyrimidine biosynthesis. wikipedia.org
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5-Fluoroorotic acid
5-Fluoroorotic acid (5FOA) is a fluorinated derivative of the pyrimidine precursor orotic acid. wikipedia.org
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Orotate reductase (NADPH)
Other names in common use include orotate reductase, dihydroorotate dehydrogenase, dihydro-orotic dehydrogenase, L-5,6-dihydro-orotate:NAD+ oxidoreductase wikipedia.org
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Ornithine transcarbamylase deficiency
The increased orotic acid concentrations result from the buildup of carbamoyl phosphate. When this induced enzymatic block is combined with reduced physiologic enzyme activity as seen in heterozygotes, the elevation of orotic acid could be wikipedia.org
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Orotidine 5'-monophosphate
If UMP synthase is defective, orotic aciduria can result. References Nucleotides Pyrimidinediones wikipedia.org
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Ornithine transcarbamylase
Orotic acid is a product of this pathway. Increased levels of orotic acid in urine can be an indicator that a patient is suffering from a disorder linked to hyperammonemia. wikipedia.org
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Uridine triacetate
Uridine triacetate (INN), formerly known as vistonuridine, is an orally active tri-acetylated prodrug of uridine used: in the treatment of hereditary orotic wikipedia.org
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