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lactam
lactam Chem. (ˈlæktæm) [a. G. lactam (Baeyer & Oekonomides 1882, in Ber. d. Deut. Chem. Ges. XV. 2102), f. lact-on lactone + am-id amide.] Any of the class of cyclic amides analogous to the lactones, characterized by the group {b1}NH·CO{b1} as part of a ring (lactam ring) and formed by the eliminati...
Oxford English Dictionary
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Lactam
At lower temp (−78 °C), β-lactam is the preferred product. At optimum temperatures, a highly useful γ-lactam known as Vince Lactam is obtained. β-Lactam
β-Lactam antibiotics, which includes penicillins
2-Pyrrolidone
2-Piperidinone
Caprolactam
References
External links
Functional groups
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PPT - β -lactam antibiotics ( β - 内酰胺类抗生素) PowerPoint Presentation - ID ...
放线菌病. Mechanism of penicillin • β-Lactam antibiotics work by binding to transpeptidase and then inhibiting the formation of peptidoglycan cross-links in the bacterial cell wall. Peptidoglycan(肽聚糖) is a 3D molecule Cross links are both horizontal and vertical between glycan chains stacked atop one another.
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Ojima lactam
The Ojima lactam is an organic compound of some importance in the commercial production of Taxol. This lactam was first synthesized by Iwao Ojima. In order to ensure the correct stereochemistry (the phenyl group and the silyl ether must adopt a cis configuration) in the β-lactam a chiral auxiliary
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lactamase
lactamase Biochem. (ˈlæktəmeɪz, -s) [f. lactam + -ase.] β-lactamase: any of the enzymes (produced by certain bacteria) which cause the breaking of the carbon-nitrogen bond in the lactam ring of penicillins and cephalosporins (so rendering them ineffective as antibiotics).1964 Jrnl. Gen. Microbiol. X...
Oxford English Dictionary
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Vince lactam
Vince lactam is the commercial name given to the bicyclic molecule γ-lactam 2-azabicyclo[2.2.1]hept-5-en-3-one. Vince's work with this lactam eventually led to his synthesis of abacavir. Peramivir synthesis is also dependent on Vince lactam starting material.
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Beta-lactam
A beta-lactam (β-lactam) ring is a four-membered lactam. The simplest β-lactam possible is 2-azetidinone.
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Tabtoxinine β-lactam
Tabtoxinine β-lactam is a monobactam antibiotic derived from tabtoxin. Unlike other β-lactam antibiotics, which inhibit penicillin-binding proteins, tabtoxinine β-lactam inhibits glutamine synthetase.
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Can ampicillin resistant bacteria survive penicillin plate? in my molecular bio class we were asked a trick question: If the bacteria has a plasmid with that grants it ampicillin ressistance, can the bacteria surviv...
Beta-lactamase hydrolyses the beta-lactam ring, which is the 4-membered ring that has the carbonyl group and the nitrogen in the ring. As both ampicillin and penicillin are closely related beta-lactam antibiotics, and have the same beta-lactam ring moiety which is the substrate of beta-lactamase
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2-aminohexano-6-lactam racemase
In enzymology, a 2-aminohexano-6-lactam racemase () is an enzyme that catalyzes the chemical reaction
L-2-aminohexano-6-lactam D-2-aminohexano-6-lactam Hence, this enzyme has one substrate, L-2-aminohexano-6-lactam, and one product, D-2-aminohexano-6-lactam.
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Asymmetric δ-Lactam Synthesis with a Monomeric Streptavidin ... - PubMed
Reliable design of artificial metalloenzymes (ArMs) to access transformations not observed in nature remains a long-standing and important challenge. We report that a monomeric streptavidin (mSav) Rh(III) ArM permits asymmetric synthesis of α,β-unsaturated-δ-lactams via a tandem C-H activation and [ …
pubmed.ncbi.nlm.nih.gov
The origin of the β-lactam carbons of clavulanic acid | Semantic Scholar
DOI: 10.1039/A701934C Corpus ID: 84191555; The origin of the β-lactam carbons of clavulanic acid @article{Thirkettle1997TheOO, title={The origin of the $\beta$-lactam carbons of clavulanic acid}, author={Jan E. Thirkettle and Jack E. Baldwin and Jeff Edwards and John Griffin and Christopher J. Schofield}, journal={Chemical Communications}, year={1997}, pages={1025-1026}, url={https://api ...
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Beta-lactam antibiotics Flashcards | Quizlet
Start studying Beta-lactam antibiotics. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
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Beta-lactam antibiotics
β-lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a beta-lactam ring in their chemical
structure. See also
List of β-lactam antibiotics
ATC code J01C Beta-lactam antibacterials, penicillins
ATC code J01D Other beta-lactam antibacterials
Bacteria
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Β-Lactamase inhibitor
the beta-lactam. the beta-lactam ring in the process.
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