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heterochronic

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heterochronic
heterochronic, a. Biol. and Path. (-ˈkrɒnɪk) [f. hetero- + Gr. χρόνος time, χρονικός of or concerning time.] a. ‘Occurring at different times; irregular; intermittent: applied to the pulse’ (Mayne Expos. Lex. 1854). b. Occurring or developed at an abnormal time. So ‖ heterochronia (-ˈkrəʊnɪə), heter... Oxford English Dictionary
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heterochronous
heteˈrochronous, a. [f. as prec. + -ous.] a. Path. = heterochronic a.1854 [see heterochronic a.]. b. Palæont. [ad. G. heterochron (E. Mojsisovics Die Cephalopoden der Hallstätter Kalke (1893) II. 5).] Originating or formed at different periods.1895 [see homœomorphy]. 1913 Q. Jrnl. Geol. Soc. LXIX. 1... Oxford English Dictionary
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Caenorhabditis elegans
Many heterochronic genes code for microRNAs, which repress the expression of heterochronic transcription factors and other heterochronic miRNAs. miRNAs It is believed that the heterochronic pathway represents an evolutionarily conserved predecessor to circadian clocks. wikipedia.org
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Parabiosis
Known as heterochronic parabiosis, this process has been used in studies to investigate the age-related and disease-related changes in the composition wikipedia.org
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Mir-48
It acts in the heterochronic pathway, where it controls the timing of cell fate decisions in the vulva and hypodermis during larval development. wikipedia.org
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Thomas A. Rando
In 2005, Rando’s laboratory was the first to use the technique of heterochronic parabiosis to explore the effects of the systemic circulation on stem cell studies of the epigenetics of stem cell aging, exploring the role of “epigenetic rejuvenation” as an explanation for the paradigm-shifting findings of heterochronic wikipedia.org
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H. Robert Horvitz
In 1981, they identified and characterized the gene lin-4, a "heterochronic" mutant that changes the timeline of cell fates. He has also continued work on heterochronic mutants and other aspects of cell lineage, and established lines of research in signal transduction, morphogenesis wikipedia.org
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Mark Katakowski
Katakowski's 2017 work hypothesizes that rejuvenating the bone marrow by autologous heterochronic transplantation of cells could extend healthy lifespan wikipedia.org
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返朴
参考文献Lee RC，Feinbaum RL，Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.Cell.1993;75(5):843- 854.doi:10.1016/0092-8674(93)90529-yWightman B，Ha I，Ruvkun G.Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal m.huxiu.com
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LIN28
In nematodes, the LIN28 homolog lin-28 is a heterochronic gene that determines the onset of early larval stages of developmental events in C. elegans, wikipedia.org
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Nature | 全面揭开线虫神经系统时间转换图谱 - 知乎
进一步地，为了对线虫中神经系统时间转换过程调节的具体分子机制进行研究，作者将目光集中在了异时性信号通路（Heterochronic pathway）上，该信号通路包含一系列microRNA、RNA结合蛋白以及转录因子 （图3） ，最初该信号通路被发现与有丝分裂外胚层谱系和生殖 ...
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Lin-4 microRNA precursor
Consequences include heterochronic developmental patterns, with loss of structures such as the vulva and adult cuticle. lin-4 acts as a negative regulator wikipedia.org
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Clive McCay
Another of McCay's important contributions was the first work in heterochronic parabiosis: the joining of the circulatory systems of a young and an old wikipedia.org
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Branchiosauridae
In the Apateon-clade different morphotypes evolved due to heterochronic changes. wikipedia.org
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Mosaic evolution
Thus a "heterochronic clock" has three variants: 1) time, as a straight line; 2) general size, as a curved line; 3) shape, as another curved line. That is insufficient to understand heterochronic mechanism. wikipedia.org
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