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heparin
heparin Biochem. (ˈhɛpərɪn) [f. hepar + -in1.] A sulphated polysaccharide present in various body tissues and organs, esp. the liver, lungs, and muscles, and used therapeutically as an anti-coagulant.1918 Howell & Holt in Amer. Jrnl. Physiol. XLVII. 328 A phosphatid, not previously described, which ... Oxford English Dictionary
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Heparin
Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. effect of heparin. wikipedia.org
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Heparin-induced thrombocytopenia - WikEM
Pathologic activation / consumption of platelets due to antibodies against heparin-platelet complex. Can be caused by unfractionated heparin or LMWH (10 times more common in unfractionated) Occurs in 0.5-5% of patients treated with heparin [1] Thrombosis occurs in 35-75% of patients ; 20-30% die within 1 month [1] HYPER-coagulable, despite low ...
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Heparin-Induced Thrombocytopenia - Medscape
Heparin-induced thrombocytopenia (HIT) is a complication of heparin therapy. [ 1] There are two types of HIT. Type 1 HIT presents within the first 2 days after exposure to heparin, and the platelet count normalizes with continued heparin therapy. Type 1 HIT is a nonimmune disorder that results from the direct effect of heparin on platelet ...
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Heparin-Induced Thrombocytopenia - HIT | Choose the Right Test
Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse effect of heparin treatment. 1 2 On exposure to heparin, some patients form antibodies that target complexes of platelet factor 4 (PF4) and heparin. Only a subset of patients with detectable antibodies develop HIT syndrome. 1 Although HIT is a thrombocytopenic disorder, it ...
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Heparin-induced thrombocytopenia - Knowledge @ AMBOSS
Nov 20, 2023Heparin-induced thrombocytopenia (HIT; formerly called type 2 HIT) is an immune-mediated prothrombotic disorder characterized by a sudden drop in platelet count (typically > 50% from baseline) in a patient receiving heparin-containing products.It typically occurs within 5-10 days of heparin initiation, but it can occur earlier in patients with recent prior heparin exposure.
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Heparin-Induced Thrombocytopenia (HIT): What to Know - WebMD
Nonimmune HIT isn't harmful, and it causes a mild dip in your platelet count. It happens to 10% of people with HIT. If you get it, your body will recover about 4 days after you stop taking heparin.
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Management of heparin-induced thrombocytopenia - UpToDate
Oct 27, 2023Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of exposure to heparin (ie, unfractionated heparin, low molecular weight [LMW] heparin) that occurs in up to 5 percent of patients exposed, regardless of the dose, schedule, or route of administration. HIT results from an autoantibody directed against platelet factor 4 ...
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Heparin Induced Thrombocytopenia: Symptoms & Treatment - Cleveland Clinic
HIT I: Your platelet levels may drop within the first few days of taking heparin but then return to normal. This type of HIT doesn't put you at risk of blood clots and doesn't require treatment. HIT II: Your body's immune system activates your platelets in response to heparin. This reaction causes your platelet levels to drop and puts you ...
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Heparin-induced thrombocytopenia - About the Disease - Genetic and Rare ...
Heparin-induced thrombocytopenia (HIT) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). HIT is usually an immune response which typically occurs 4-10 days after exposure to heparin. It can lead to serious complications.
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Heparin-induced thrombocytopenia
people who are receiving heparin. receiving heparin. wikipedia.org
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Function of heparin and dextran sulfate for removing proteins From this article : > The reaction was terminated and the histones, and most nonhistones, were removed by adding the nuclease-treated chromosomes to a sol...
Heparin and dextran are polyanions which form insoluble salts with the cationic histones.(Dextran is a polymer of glucose. Immobilised heparin is sometimes used as an affinity matrix for purification of DNA-binding proteins like transcription factors.
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Clinical presentation and diagnosis of heparin-induced ... - UpToDate
Oct 25, 2023Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of exposure to heparin (eg, unfractionated heparin, low molecular weight [LMW] heparin) that occurs in a small percentage of patients exposed, regardless of the dose, schedule, or route of administration. HIT results from an autoantibody directed against endogenous ...
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Heparin-induced thrombocytopenia - Wikipedia
Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count), due to the administration of various forms of heparin, an anticoagulant.HIT predisposes to thrombosis (the abnormal formation of blood clots inside a blood vessel).When thrombosis is identified the condition is called heparin-induced thrombocytopenia and thrombosis (HITT).
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Heparin lyase
The enzyme heparin lyase () catalyzes the following process: Eliminative cleavage of polysaccharides containing (1→4)-linked D-glucuronate or L-iduronate The systematic name of this enzyme class is heparin lyase. Other names in common use include heparin eliminase, and heparinase. wikipedia.org
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