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DEDIFFERENTIATION Definition & Meaning - Merriam-Webster
de·dif·fer·en·ti·a·tion (ˌ)dē-ˌdi-fə-ˌren-chē-ˈā-shən. : reversion of specialized structures (such as cells) to a more generalized or primitive condition often as a preliminary to major physiological or structural change . dedifferentiate.
www.merriam-webster.com
www.merriam-webster.com
Dedifferentiation - Wikipedia
a transient process by which cells become less specialized and return to an earlier cell state within the same lineage.
en.wikipedia.org
en.wikipedia.org
Dedifferentiation: inspiration for devising engineering strategies for ...
Cell dedifferentiation is the process by which cells grow reversely from a partially or terminally differentiated stage to a less differentiated stage within ...
www.nature.com
www.nature.com
dedifferentiation
dedifferentiation Biol. (ˌdiːdɪfərɛnʃɪˈeɪʃən) [ad. F. dédifférentiation (C. Champy): see de- II. 2.] The loss or reversal of differentiation (see differentiation 1). Hence ˌdediffeˈrentiate v. intr., to undergo such a process; ˌdediffeˈrentiated ppl. a.1917 Amer. Jrnl. Anat. XXII. 188 Dedifferentiat...
Oxford English Dictionary
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An orderly retreat: Dedifferentiation is a regulated process - PMC
Dedifferentiation is characterized by a loss of developmental markers and a subsequent gain of proliferative capacity (6, 7, 45), but these characteristics do ...
pmc.ncbi.nlm.nih.gov
pmc.ncbi.nlm.nih.gov
Cell Dedifferentiation - an overview | ScienceDirect Topics
Dedifferentiation is a process by which cells develop in reverse, from a more differentiated to a less differentiated state [33]. This transition involves ...
www.sciencedirect.com
www.sciencedirect.com
Dedifferentiation of committed epithelial cells into stem cells in vivo
Dedifferentiated cells were morphologically indistinguishable from stem cells and they functioned as well as their endogenous counterparts to repair epithelial ...
pmc.ncbi.nlm.nih.gov
pmc.ncbi.nlm.nih.gov
[PDF] Dedifferentiation, transdifferentiation and reprogramming
However, the cells fail to retain their differentiated status; they dedifferentiate to an earlier eyeprecursor stage and show unrestricted proliferation.
bme.unc.edu
bme.unc.edu
Dedifferentiation: A New Approach in Stem Cell Research
Dedifferentiation is a process by which cells develop in reverse, from a more differentiated to a less differentiated state. The phenomenon can ...
academic.oup.com
academic.oup.com
Dedifferentiation, transdifferentiation and cell fusion: in vivo ...
Dedifferentiation: The term dedifferentiation is intrinsically associated with lineage reprogramming, meaning that fully differentiated cells ...
febs.onlinelibrary.wiley.com
febs.onlinelibrary.wiley.com
Reversine
Schultz, used for stem cell dedifferentiation.
It also has the potential to selectively induce cell death in cancer cells.
wikipedia.org
en.wikipedia.org
The role of RNA-binding and ribosomal proteins as specific RNA ...
This demonstrates the important role of RNA-binding proteins, specific ribosome-binding proteins and microRNAs as key molecules in controlling the specific proteins required for the differentiation or dedifferentiation of cells. ... Deregulation of miR-373 has been demonstrated in several cancers, and it can act as either an oncogene or a ...
www.sciencedirect.com
News Homepage - News Center | The University of Texas at Dallas
Researchers Find More Complexity in Aging Brain's Memory Decline. March 15, 2024. Sabina Srokova PhD'22 and Dr. Michael Rugg discovered that age-related neural dedifferentiation is driven by multiple mechanisms, a finding that could affect efforts to preserve cognitive health in older people.
news.utdallas.edu
Pluripotency (biological compounds)
See also
Induced pluripotent stem cell
Directed differentiation
Dedifferentiation
References
Developmental biology
Immunology
Stem cells
wikipedia.org
en.wikipedia.org
Anaplasia
It implies dedifferentiation, or loss of structural and functional differentiation of normal cells. It is now known, however, that at least some cancers arise from stem cells in tissues; in these tumors failure of differentiation, rather than dedifferentiation
wikipedia.org
en.wikipedia.org