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aldosterone
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aldosterone
aldosterone Biochem. (ˌældəʊˈstɛrəʊn, -ˈstɪərəʊn) [f. aldo- + sterol + -one.] A steroid hormone isolated from the adrenal gland. Hence ˌaldoˈsteronism, a disease characterized by excessive amounts of aldosterone in the blood and urine.1954 Lancet 12 June 1226/2 Because of the presence of an aldehyde...
Oxford English Dictionary
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Tired? Dizzy? Craving Salt? Could Be Low Aldosterone
The natural increase in blood pressure that occurs in the doctor's office, known as "white-coat hypertension," can give a reading that's artificially high. If you have low aldosterone, your blood pressure could be as low as 90/60. (Normal is about 120/80.) Another key symptom of low aldosterone is the intense craving for salt.
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Aldosterone synthase
Metabolism
Aldosterone synthase converts 11-deoxycorticosterone to corticosterone, to 18-hydroxycorticosterone, and finally to aldosterone:
In human Deficient aldosterone synthase activity results in impaired biosynthesis of aldosterone while corticosterone in the zona glomerulosa is excessively produced
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Aldosterone escape
In physiology, aldosterone escape is a term that has been used to refer to two distinct phenomena involving aldosterone that are exactly opposite each is often seen in these patients, which is the direct result of aldosterone-induced expression of ENaC channels.
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Hypoaldosteronism
Hypoaldosteronism is an endocrinological disorder characterized by decreased levels of the hormone aldosterone. Primary aldosterone deficiency
Primary adrenal insufficiency
Congenital adrenal hyperplasia (21 but not 11β and 17)
Aldosterone synthase deficiency
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Primary aldosteronism
Rather, both renin and aldosterone are measured, and a resultant aldosterone-to-renin ratio (ARR) is used for case detection. A high aldosterone-to-renin ratio suggests the presence of primary hyperaldosteronism.
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Glucocorticoid remediable aldosteronism
It selectively stimulates secretion of aldosterone.
The secretion of aldosterone has a diurnal rhythm. which is a precursor of aldosterone.
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Aldosterone-to-renin ratio
Aldosterone-to-renin ratio (ARR) is the mass concentration of aldosterone divided by the plasma renin activity or by serum renin concentration in blood Also, the inverse value is occasionally given, that is, the renin-to-aldosterone ratio, whose value is the multiplicative inverse of the aldosterone-to-renin
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Journal of the Renin-Angiotensin-Aldosterone System
Journal of the Renin-Angiotensin-Aldosterone System is a peer-reviewed academic journal that publishes papers in the field of Peripheral Vascular Disease with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals.
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Feline hyperaldosteronism
One type is caused by a unilateral aldosterone-producing adenoma or adenocarcinoma. Aldosterone activates sodium channels that result in sodium resorption from the urine.
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11-Deoxycorticosterone
Corticosterone is then converted to aldosterone by aldosterone synthase. Therefore, DOC must be indirectly inhibiting aldosterone since aldosterone depends on angiotensin II.
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18-Hydroxycorticosterone
Function
18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa. See also
18-Hydroxycortisol
Aldosterone synthase
References
Corticosteroids
Pregnanes
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Antimineralocorticoid
the action of aldosterone at mineralocorticoid receptors. Mineralocorticoid receptor antagonists decrease the aldosterone effect by binding to the mineralocorticoid receptor inhibiting aldosterone.
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