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actinomycin
actinomycin Biochem. (ˈæktɪnəʊˈmaɪsɪn) [f. actino- + Gr. µύκης fungus + -in1.] An antibiotic substance of the actinomycetes group originally isolated by S. A. Waksman and H. B. Woodruff from certain micro-organisms found in soil.1940 Proc. Soc. Exper. Biol. XLV. 610 The active substance was tentativ...
Oxford English Dictionary
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Actinomycin lactonase
The enzyme actinomycin lactonase (EC 3.1.1.39) catalyzes the reaction
actinomycin + H2O actinomycinic monolactone
This enzyme belongs to the family The systematic name is actinomycin lactonohydrolase.
References
EC 3.1.1
Enzymes of unknown structure
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7-Aminoactinomycin D
Actinomycin D
The related compound actinomycin D is nonfluorescent, but binds DNA in the same way as 7-AAD.
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-mycin
-mycin, suffix Pharmacol. (ˈmaɪsɪn) [f. Gr. µύκης fungus + -in1.] Used to form the names of antibiotic compounds derived from fungi, usu. with part of the generic name or specific epithet of the fungus, as actinomycin, erythromycin, streptomycin, etc.
Oxford English Dictionary
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Actinomycetales
Streptomycin, actinomycin, and streptothricin are all medically important antibiotics isolated from Actinomycetes bacteria.
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clavacin
clavacin Biochem. (ˈklævəsɪn) Also clavicin. [f. L. clāvā(tus (see clavate a.) as in mod.L. Aspergillus clavatus, a species of fungi + -cin as in actinomycin, etc.; see -in1.] A crystalline antibiotic substance produced in several fungi; spec. that obtained from Aspergillus clavatus.1942 S. A. Waksm...
Oxford English Dictionary
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Dactinomycin
Dactinomycin, also known as actinomycin D, is a chemotherapy medication used to treat a number of types of cancer. Actinomycin is a vesicant, if extravasation occurs.
Mechanism
In cell biology, actinomycin D is shown to have the ability to inhibit transcription.
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Choriocarcinoma
As of 2019, treatment with either single-agent methotrexate or actinomycin-D is recommended for low-risk disease, while intense combination regimens including EMACO (etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine (Oncovin) are recommended for intermediate or high-risk disease.
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Streptomyces showdoensis
Streptomyces showdoensis produces terferol, actinomycin and showdomycin.
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Streptomyces michiganensis
Streptomyces michiganensis produces actinomycin X, antipain and mitomycin.
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Streptomyces sindenensis
Streptomyces sindenensis produces actinomycin-D and the amicetin complex
See also
List of Streptomyces species
References
Further reading
External
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Streptomyces regensis
Streptomyces regensis produces actinomycin and cyanohydrin phosphonate.
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Streptomyces iakyrus
Streptomyces iakyrus is a bacterium species from the genus of Streptomyces which has been isolated from soil Streptomyces iakyrus produces actinomycin G2, actinomycin G3, actinomycin G4, actinomycin G5, actinomycin G6, iakirine I, iakirine II and iakirine III.
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Streptomyces antibioticus
Upon its discovery, it was found that S. antibioticus produced a then novel substance named Actinomycin. This substance was then separated into two compounds: Actinomycin A and Actinomycin B.
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Streptomyces parvus
Streptomyces parvus produces the actinomycin C complex, arylomycin A5, arylomycin A6 and actinomycin D.
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