melphalan, n. Pharm.
(ˈmɛlfəˌlæn)
[f. methyl n. + L 8 c (ii) + phenylalanine n.]
A nitrogen mustard given intravenously in the treatment of myelomatosis and other neoplasms; 4-bis(2-chloroethyl)amino-l-phenylalanine, C13H18N2O2Cl2 .
| 1960 Cancer Chemotherapy Rep. Feb. 61 Melphalan. 1962 Surgery LI. 583/1 Phenylalanine mustard exists in two forms. One is the dl form called Sarcolysin; the other is the l form called melphelan [sic]. 1974 R. M. Kirk et al. Surgery v. 73 When excision is not possible..it is worth trying the effects of..systemic chemotherapy with phenylalanine mustard drugs, or melphalan given systemically. 1977 Lancet 18 June 1307/1 In our similar studies of 8 patients menstruating regularly plasma œstradiol and androgens were measured frequently at random before and after five-day pulses of melphalan. 1992 Sci. News 27 June 420/2 Melphalan, seldom used anymore in adjuvant therapy, poses roughly 10 times the leukemia risk. |