glyoxalase Biochem.
(glaɪˈɒksəleɪz, -s)
[f. prec. + -ase.]
Either of two enzymes which together convert methylglyoxal to lactic acid in the presence of glutathione; orig. considered a single enzyme.
| 1913 Dakin & Dudley in Jrnl. Biol. Chem. XIV. 423 The catalyst..effects the rapid conversion of methyl glyoxal into lactic acid... We propose that it be named ‘glyoxalase’. 1951 Ibid. CXC. 685 The first step consists in a condensation reaction between methylglyoxal and glutathione catalyzed by an enzyme referred to in this paper as glyoxalase I. This condensation product, in a second step which is catalyzed by glyoxalase II, is then broken down into glutathione and lactic acid. 1961 Biochem. Jrnl. LXXIX. 481/1 Ophthalmic acid..was a competitive inhibitor in the reaction catalysed by glyoxalase I. |