iproniazid Pharm.
(aɪprɒˈnaɪəzɪd)
[f. i(so)pro(pyl (s.v. iso- b) + isoniazid (iproniazid being the isopropyl derivative of isoniazid).]
A derivative of isoniazid which was used for a time (usually as the phosphate, a white crystalline powder) in the treatment of tuberculosis and as an antidepressant; 1-isonicotinyl-2-isopropyl hydrazine, (CH3)2CH·NH·NH·CO·C5H4N.
| 1953 Amer. Rev. Tuberculosis & Pulmonary Dis. LXVII. 214 A definite pattern of withdrawal has been observed following discontinuance of isoniazid and iproniazid therapy. 1960 Times 4 Mar. 15/7 Yet another of the psychotropic drugs now being used, iproniazid, reverses the effect of reserpine. 1968 W. C. Bowman et al. Textbk. Pharmacol. xxiii. 623 The antitubercular drug iproniazid..possesses marked antidepressant activity and inhibits MAO [sc. monoamine oxidase]... Iproniazid may cause a number of side-effects, the most serious being acute hepatic necrosis which is occasionally fatal. Because of this, the use of iproniazid as an antidepressant has been discontinued. 1971 Brit. Med. Bull. XXVII. 28/2 Hypertensive attacks were described in patients who were given iproniazid for tuberculosis. |