triamterene, n. Pharm.
(traɪˈæmtəriːn)
Also triamterine.
[f. triamine n. + -terene altered f. pteridine n.]
A yellow crystalline powder, C12H11N7 , used as a mild diuretic, usu. as an adjunct to other diuretic drugs in cases where increased excretion of potassium is undesirable; 6-phenylpteridine-2,4,7-triamine.
| 1962 Ann. Internal Med. LVI. 241/1 Observations in rats and dogs..demonstrated that triamterene (SK&F No. 8542)..possessed antimineralo-corticoid activity. 1964 Brit. Med. Jrnl. 13 June 1557/1 Triamterine is a pteridine compound (2,4,7-triamino-6-phenylpteridine) and is chemically unrelated to any of the previously available diuretics. 1970 Passmore & Robson Compan. Med. Stud. II. xi. 10/1 Triamterene increases the renal excretion of Na+ and Cl- in approximately equal amounts and has no effect on HCO3- excretion. 1985 Brit. Med. Jrnl. 9 Nov. 1337/1 Folate may be antagonised by..triamterine. 1987 M. J. Neal Med. Pharmacol. xiii. 33/2 Amiloride and triamterene decrease the luminal membrane Na+ permeability in the distal nephron. |