phthiocol Biochem.
(ˈfθaɪəkɒl)
[f. phthisis + -o + -col (perh. f. alcohol).]
A yellow crystalline pigment, 3-hydroxy-2-methyl-1,4-naphthoquinone, C11H8O3, originally isolated from tubercle bacilli, which has the action of vitamin K.
| 1933 Anderson & Newman in Jrnl. Biol. Chem. CIII. 197 In order to indicate its origin, we propose to designate the pigment by the name phthiocol. 1954 H. J. Almquist in Sebrell & Harris Vitamins II. ix. 393 Synthetic phthiocol tested with vitamin K-deficient chicks was found to be distinctly active in restoring normal blood-clotting time and thus became the first completely identified form of vitamin K. 1960 A. E. Bender Dict. Nutrition 133/2 Natural vitamin K chemically is a phylloquinone... The synthetic materials, menadione..and phthiocol (2-methyl-3-hydroxy-1:4-naphthoquinone), are more active than the naturally occurring vitamins. 1964 Asselineau & Lederer in V. C. Barry Chemotherapy of Tuberculosis i. 21 Phthiocol..isolated..after saponification of mycobacterial fat, is an artefact, produced from a vitamin K-like polyisoprenoid naphthoquinone. |