hypertensin Biochem.
(haɪpəˈtɛnsɪn)
[f. hypertension, -ive a. + -in1.]
Either of two polypeptides, of which one (hypertensin I) is formed in the blood by the action of renin on a protein (hypertensinogen), and the other (hypertensin II) is derived from it by the loss of two amino-acid residues, causes a rise in blood pressure, and stimulates the secretion of aldosterone; also, analogous polypeptides in animals. Now usually called angiotensin.
| 1939 J. M. Muñoz et al. in Nature 9 Dec. 980/1 This substance, which we name hypertensin, is different from adrenalin, tyramin, pitressin and urohypertensin. 1954 Jrnl. Exper. Med. XCIX. 282 Two types of hypertensin have been demonstrated... The first type..has been designated hypertensin I. It can be rapidly converted to a second, approximately equally pressor compound, hypertensin II. 1956 Nature 17 Mar. 527/2 The isolation and purification of a hypertensin peptide, resulting from the action of rabbit renin on ox serum. 1959 A. White et al. Princ. Biochem. (ed. 2) xxx. 750 Hypertensin I preparations of slightly different composition have been described, depending on the sources of the renin and the substrate used. Ibid., Hypertensin has also been called angiotonin. A uniform nomenclature has been proposed which would designate this compound as angiotensin. |
Hence ˌhypertenˈsinogen [ad. F. hypertensinogène (E. Braun-Menendez 1940, in Compt. Rend. de la Soc. de Biol. CXXXIV. 489): see -ogen], a globulin produced by the liver and present in blood, from which hypertensin I may be liberated by renin.
| 1941 Amer. Jrnl. Physiol. CXXXV. 214 Braun-Menendez has preferred the term hypertensinogen, which implies that it is the substrate on which renin acts. 1965 New Scientist 25 Nov. 561/3 Kidney cells, in the presence of a poor blood flow.., secreted an enzyme called renin which converted a normal constituent of plasma (hypertensinogen) into a new substance (hypertensin). |