progestogen Physiol.
(prəʊˈdʒɛstədʒɛn)
Also progestagen.
[f. as prec. + -o + -gen; the variant spelling may reflect the influence of gestagen.]
= gestagen.
| 1941 Dorland & Miller Med. Dict. (ed. 19) 1171/2 Progestogen, a general term for any substance possessing progestational activity. 1945 [see progestin]. 1962 Lancet 12 May 1012/1 In those premature labours where relaxation of the cervix precludes uterine contractions, such measures as cervical suture and the administration of progestogens can prevent disaster. 1968 Passmore & Robson Compan. Med. Stud. I. xxxvii. 11/1 The principal ovarian hormones..fall into three broad functional categories, oestrogens, progestagens and androgens. Ibid. 14/2 A more useful pharmacological definition of a progestagen is a substance which induces secretory changes in an oestrogen-primed endometrium. 1968 Times 28 Nov. 14/4 Most oral contraceptive pills contain both a progestogen and an oestrogen. 1977 Lancet 21 May 1101/2, 7 women..used low-dose progestagen pills. |
Hence progestoˈgenic a. = progestational a.
| 1949 H. E. Nieburgs Hormones in Clin. Pract. viii. 176 The progestogenic preparations are mainly employed for the prevention and treatment of habitual and threatened abortion. 1969 Sunday Times 14 Sept. 54/3 The remedy may be a change to a more ‘progestogenic brand’ [of oral contraceptive]. 1973 Nature 9 Mar. 88/1 Administration of sex hormones or their analogues, whether androgenic, oestrogenic or progestogenic, can produce temporary remission in about one-quarter to one-third of patients with advanced breast cancer. 1977 Lancet 19 Nov. 1085/1 Evidence is accumulating to indicate that it is principally the œstrogenic and not the progestagenic component of combined oral-contraceptive preparations which causes the acceleration of blood-clotting. |