ethionamide Pharm.
(ɛθɪˈɒnəmaɪd)
[Blend of ethyl and thion- + amide.]
An antibiotic, C8H10N2S, which is active against mycobacteria and has been used to treat tuberculosis.
| 1960 Tubercle XLI. 367 Ethionamide..is given orally in small bulk, is highly effective and is of low toxicity. 1974 [see pyrazinamide]. 1983 Oxf. Textbk. Med. I. v. 254/1 The use of ethionamide and prothionamide..is limited by their adverse effects, notably gastrointestinal irritation. 1984 Brit. Med. Jrnl. 25 Aug. 496/1 It is difficult to establish whether liver damage has been due to rifampicin or one of its companion drugs (such as isoniazid and ethionamide), which may form potentially hepatotoxic combinations with rifampicin. |