alprenolol, n. Pharm.
(ælˈprɛnəlɒl)
[f. allyl + isoprenaline n. + *-olol.]
A beta blocker given orally as the hydrochloride in the treatment of hypertension, angina, and cardiac arrhythmias; 1-(2-allylphenoxy)-3-isopropylaminopropan-2-ol, C15H23NO2 .
| 1968 WHO Chron. XXII. 112 Alprenolol. 1969 Amer. Heart Jrnl. LXXVII. 598/1 Alprenolol was introduced in 1966 by A. B. Hassle Laboratory of Sweden and has had limited clinical trial. 1970 Brit. Jrnl. Pharmacol. XL. 380 The stimulant effects of alprenolol were also blocked by propranolol. 1977 Lancet 22 Oct. 850/1 Propranolol, alprenolol, and oxprenolol block the peripheral β-receptors mediating vasodilatation at lower concentrations than are required to block cardiac β-receptors. 1980 Brit. Med. Jrnl. 29 Mar. 888/2 Beta-blockade may have harmed some patients and helped others: the recent alprenolol study has shown a differential effect in patients aged under and over 65. |