urogastrone Biochem.
(jʊərəʊˈgæstrəʊn)
[f. uro-1 + gastric a. + -one; cf. enterogastrone s.v. entero-.]
Any of a number of closely related humoral agents in mammalian urine which retard gastric secretion and motor activity.
| 1940 J. S. Gray et al. in Proc. Soc. Exper. Biol. & Med. XLIII. 228 Until such time as the gastric inhibitory factor is definitely identified, we propose to call it urogastrone. 1946 Nature 31 Aug. 305/1 (heading) Urease in the gastric mucosa and its increase after a meat diet, soya bean flour diet or urogastrone injections. 1966 Wright & Symmers Systemic Path. I. xiv. 494/1 Extracts of normal urine contain a substance, urogastrone, that inhibits the action of pepsin and hydrochloric acid. 1975 Nature 25 Sept. 325/1 The two urogastrones were shown to be water-soluble polypeptides of relatively low molecular weight and the difference between them could be shown by various physical techniques including acrylamide gel electrophoresis. |