pronethalol, n. Pharm.
(prəʊˈnɛθəlɒl)
Also pronetalol (-ˈnɛt-).
[f. propyl n. + naphthyl n. + ethanol n. + *-olol]
A beta-adrenoceptor blocking drug, 2-isopropylamino-1-(2-naphthyl)ethanol, C15H19NO , formerly used in the treatment of angina and cardiac dysrhythmias. Superseded by its structural derivative, propranolol.
| 1963 Brit. Jrnl. Pharmacol. XXI. 63 The β-blocking agent pronethalol..significantly reduced the combined toxicity of yohimbine and imipramine. 1964 WHO Chron. XVIII. 439 Pronetalol. 1972 Materials & Technol. V. xxi. 810 Beta receptor blocking drugs such as propranolol and pronethalol find their application in the treatment of certain cardiac conditions. 1987 Molecular Pharmacol. XXXI. 101/2 Drugs with higher lipophilicity, such as exaprolol, Kö-1124, alprenolol, propranolol, metipranolol, doberol, and pronethalol, had a severalfold higher perturbation effect at the hydrocarbon membrane core than at the region close to the polar lipid part. |