cocarboxylase Chem.
(ˌkəʊkɑːˈbɒksɪleɪs)
[G. (E. Auhagen 1932, in Zeitschr. f. physiol. Chem. CCIV. 149), f. co- + carboxylase.]
Thiamine pyrophosphate or diphosphothiamine, the co-enzyme of carboxylase and other enzymes, esp. those which act on pyruvic acid.
| 1932 Chem. Abstr. 2753 (title) Cocarboxylase, a new coenzyme of alcoholic fermentation. 1937 Biochem. Jrnl. XXXI. 2240 ‘Co-carboxylase’..has as good an effect as vitamin B1 in the catatorulin test. 1944 Ann. Reg. 1943 353 In the excitation process of peripheral nerve acetylcholine formation seems to be related to the co-carboxylase activity of vitamin B1. 1947 A. T. Henrici Molds, Yeasts (ed. 2) xi. 318 The enzyme, carboxylase, which catalyzes the decarboxylation of pyruvic acid to carbon dioxide and acetaldehyde in the alcoholic fermentation, cannot function without its coenzyme, cocarboxylase. 1961 [see apoenzyme]. |