phenytoin Pharm.
(ˈfɛnɪtəʊɪn)
[f. phenyl + hydantoïn.]
5,5-Diphenylhydantoin, C15H12N2O2, an anticonvulsant widely used in the treatment of epilepsy (usu. in the form of its sodium salt, a white powder).
| 1942 Jrnl. Amer. Med. Assoc. 4 Apr. 1209/2 While phenytoin sodium (sodium diphenyl hydrantoinate, or dilantin sodium) was effective in protecting animals from electrically induced convulsions it produced little sedative effect. 1952 A. H. Douthwaite Hale-White's Materia Medica (ed. 29) 193 When grand mal and petit mal occur in the same patient phenobarbitone and troxidone should be used together: phenytoin must not be employed. 1961 Lancet 23 Sept. 683/2 Since then, she has had post-encephalic epilepsy which is controlled by phenobarbitone and phenytoin sodium. 1969 New Scientist 10 July 57/3 Patients who had received phenobarbitone or phenytoin showed a dramatic reduction in DDE levels. 1973 [see Mysoline]. |