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soul-sickening

soul-sickening, ppl. a.
  [f. soul n. 23.]
  Extremely depressing or dejecting.

1825 J. Wilson Poems ii. 11 One soul-sickening moment of despair. 1854 Greenwood Haps & Mishaps 89 All was squalor and tatters, soul-sickening and disgusting. 1891 Kipling City Dreadf. Nt. 5 For diffused, soul-sickening expansiveness, the reek of Calcutta beats both Benares and Peshawur.

Oxford English Dictionary

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