hydroxyprogesterone Biochem. and Pharm.
(haɪˌdrɒksɪprəʊˈdʒɛstərəʊn)
[f. hydroxy- + progesterone.]
Any of several synthetic derivatives of progesterone that have a hydroxyl group in place of one of the hydrogen atoms of the steroid nucleus; esp. the derivative in which the hydroxyl group is at position 17, used (chiefly as the caproate ester) as a long-acting progestational compound in cases of corpus luteum deficiency.
| 1941 Jrnl. Biol. Chem. CXXXIX. 855 It was found to be the hitherto unknown steroid..l7-hydroxyprogesterone.., a position isomer of desoxycorticosterone. 1948 W. H. Pearlman in Pincus & Thimann Hormones I. xi. 441 Erhart and co-workers..described the preparation of 12(α)-hydroxyprogesterone..from desoxycholic acid..; the substance was found to be lacking in physiological activity. 1954 Nature 30 Oct. 839/2 Various derivatives of progesterone by oxidation at C11 such as..11-α-hydroxyprogesterone and 11-β-hydroxyprogesterone..have been found to be only about 3–10 per cent as progestational as progesterone. 1962 N. Applezweig Steroid Drugs v. 100 When administered to pregnant women for the prevention of habitual abortion, Norlutin and 17α-hydroxyprogesterone caproate have been shown on occasion to cause masculinization of the female fetus. 1968 J. H. Burn Lect. Notes Pharmacol. (ed. 9) 93 The progestogen [in contraceptive pills] is either a 19-norsteroid derivative..or a 17-hydroxy-progesterone derivative. |