piperazine Pharm.
(pɪˈpɛrəziːn, formerly ˈpɪpərəzaɪn)
[First formed as G. piperazin (A. T. Mason 1887, in Ber. d. Deut. Chem. Ges. XX. 267), f. piper(idin piperidine + azin azine.]
A colourless, crystalline, heterocyclic base, C4H10N2 which is used, in the form of a salt or hydrate, as an anthelminthic; also, a derivative of this. Also called pipeˈrazidine.
| [1888 Jrnl. Chem. Soc. LIV. 726 Diphenyldiketopiperazine.] 1889 Ibid. LVI. 1009 (heading) Piperazines. 1891 Lancet 18 Apr. 897 It is stated..that piperazidine dissolves uric acid more readily than any other substance of a basic nature. 1891 Jrnl. Chem. Soc. LX. 415 Piperazine melts at 104–107°. 1894 Muir & Morley Watts' Dict. Chem. IV. 277 Piperazine. 1897 Allbutt's Syst. Med. III. 173 Piperazine, whether in the free state or as chloride, was not found to exercise any influence on the advent of precipitation. 1901 Brit. Med. Jrnl. No. 2092 Epit. Med. Lit. 20 Piperazine is the best drug for the underlying morbid condition. 1937 Thorpe's Dict. Appl. Chem. (ed. 4) I. 315/1 Cyclic compounds are..produced by distilling the dihydrochlorides of the aliphatic diamines... Thus ethylenediamine yields piperazine. 1970 W. H. Parker Health & Dis. in Farm Animals xx. 276 Piperazine compounds might be considered the safest.., but thiabendazole has the merit of being effective against both large and small round worms in the pig. 1974 M. C. Gerald Pharmacol. ii. 35 Streptomycin, piperazine (Antepar), [etc.]..have been quite effective in the cure of tuberculosis, pinworm,..respectively. |