proband
(ˈprəʊbənd)
[ad. L. proband-us, gerundive of probāre to test, examine.]
An individual chosen as a propositus because of the presence of some trait whose inheritance is to be studied. Also attrib., as proband method, proband test.
| 1929 Resumptio Genetica IV. 296/1 (Index), Proband. 1931 E. & C. Paul tr. Baur's Human Heredity xi. 501 A graphic representation of the parents, grandparents, great-grandparents, etc., of the individual from whom an investigation starts (such a person is called a proband) is known as that person's ancestral table. Ibid. 508 The proband method is wrongly supposed to be difficult to apply. 1940 Hinsie & Shatzky Psychiatric Dict. 431/2 The practicable statistical method of probands in the study of selective population groups..is called the proband method. 1962 Lancet 29 Dec. 1341/2 Seven probands had a first-degree relative who had been treated with an antidepressant drug while under hospital care for a depressive illness. 1967 Economist 9 Dec. 1065/4 It is said that the Proband test effectively screens disease carriers in an endemic herd, and that once foreign buyers got used to it they would still want British pedigree animals. 1977 Jrnl. Med. Genetics XIV. 125/2 The same balanced translocation was found in the proband's sister, in 5 of 6 sibs of the mother and in 2 children of one of them. |