methimazole, n. Pharm.
(mɛˈθɪməzəʊl)
[f. methyl n. + imidazole n.]
An imidazole derivative with antithyroid properties, given orally in the treatment of hyperthyroidism; 1-methylimidazole-2-thiol, C3H2N2(CH3)(SH) .
| 1951 Amer. Jrnl. Med. Sci. CCXXII. 140/1 The relatively short period of methimazole therapy required to produce euthyroidism after initial iodine treatment. 1968 J. H. Burn Lect. Notes Pharmacol. (ed. 9) 86 Thiouracil has been used to treat thyrotoxicosis but it is now replaced by methimazole and carbimazole. 1977 Lancet 21 May 1105/1 Treatment with 60 mg of methimazole and 60 mg propranolol daily resulted in a clearing of his psychotic and hypomanic symptoms. 1988 Jrnl. Neural Transmission LXXI. 201 Desipramine binding was decreased in thyrotoxicosis and increased in rats treated with methimazole. |