‖ hæmophilia Path.
(hiːməʊˈfɪlɪə, hɛməʊ-)
Rarely anglicized hæmophily (hiːˈmɒfɪlɪ).
[mod.L., f. hæmo- + Gr. ϕιλία affection. Cf. Ger. hämophilie, 1828.]
A constitutional (usually hereditary) tendency to bleeding, either spontaneously or from very slight injuries; hæmorrhagic diathesis.
| 1854 Jones & Siev. Pathol. Anat. (1874) 62 Hæmophily appears to be often hereditary. 1864 Syd. Soc. Year-bk. 123 Report on Hæmophily. 1872 J. W. Legg (title) A Treatise on Hæmophilia. 1879 Khory Princ. Med. 4 Hæmophilia is..inherited almost exclusively by males, though capable of transmission through unaffected females. |
Hence hæmophiliac (-ˈfɪlɪæk) a., affected with hæmophilia; also as n., a person so affected; hæmophilic (-ˈfɪlɪk) a., affected with hæmophilia; also as n., a hæmophiliac.
| 1864 Syd. Soc. Year-bk. 124 The hæmophilic have for the most part a soft white translucent skin. 1896 Lancet 18 Jan. 153/2 An arrest of severe hæmophiliac bleeding from the gums was obtained by an application of calcium phosphate. 1897 Boston Med. & Surg. Jrnl. 11 Mar. 227/1 In hemophiliacs, leeching, extraction of the teeth and circumcision are very hazardous operations. 1897 Lippincott's Med. Dict. 454/1 Hæmophilic... 2. A person affected with hæmophilia. 1935 Whitby & Britton Disorders of Blood xiv. 272 On Mendelian principles a female may be a true hæmophilic if she is the daughter of a hæmophilia-transmitting woman and a hæmophilic male. 1936 Discovery Dec. 388/2 A preparation from egg-white, which reduces the clotting time of blood, provides new hope for haemophiliacs. 1938 New Statesman 2 July 7/2 Between thirty-five and seventy haemophilics are alive in Greater London to-day. 1946 Nature 28 Sept. 447/1 We have been able to study the effect, in some hæmophiliac patients, of a product containing 82 per cent fibrinogen. 1962 Lancet 27 Jan. 194/1 A pharmacist who is a hæmophiliac had noted that by taking hesperidin chalcone (a flavonoid) he could ward off hæmorrhagic episodes. 1966 Dunlop & Alstead Textbk. Med. Treatm. (ed. 10) 496 In centres with suitable facilities, a supply of this plasma specifically for use in hæmophilics serves a useful purpose. 1967 M. M. Wintrobe Clin. Hematol. (ed. 6) xviii. 937/1 Karyotype analysis has been carried out in several of the hemophiliac women and only in 2 instances has the karyotype been abnormal. |