promethazine Pharm.
(prəʊˈmɛθəziːn)
[f. propyl + methyl + -azine (f. azo- + -ine5).]
A bitter-tasting antihistamine compound, 10-(2-dimethylaminopropyl)phenothiazine, C17H20N2S, which is used chiefly as an anti-emetic and a sedative, usu. in the form of its hydrochloride, a white powder.
| 1951 Lancet 26 May 1143/2 ‘Avomine’ (promethazine 8-chlorotheophyllinate) is a safe and effective remedy for seasickness. 1959 Which? July 69/2 All that is certain is that hyoscine, meclozine, cyclizine and promethazine do act to prevent travel sickness, and all have some side-effects. 1961 Lancet 23 Sept. 688/1 To control shivering a mixture of promethazine hydrochloride 50 mg., pethidine 50 mg., and chlorpromazine 50 mg. was made up to 20 ml. 2–4 ml. of this mixture was administered intravenously as required. 1971 B. R. Jones Pharmacol. iii. 15 Post⁓operative vomiting is reduced by including in the premedication an intramuscular injection of either an antihistamine such as Promethazine (‘Phenergan’) or a tranquillizer of the phenothiazine type such as Promazine. |