guanase Biochem.
(ˈgwɑːneɪz, -s)
[a. G. guanase (Jones & Partridge 1904, in Hoppe-Seyler's Zeitschr. f. physiol. Chem. XLII. 347), f. guanine + -ase.]
An enzyme that hydrolyses guanine to xanthine and ammonia; guanine aminohydrolase, guanine deaminase.
| 1904 Jrnl. Chem. Soc. LXXXVI. i. 838 Fresh pancreas, when subjected to autolysis, does not yield adenine or guanine, and guanine which is added is transformed into xanthine within 3 days. The enzyme present in pancreas which induces this change is termed Guanase. 1967 Biochem. Jrnl. CIV. 634/1 Guanase (guanine aminohydrolase, EC 3.5.4.3) was of special interest as guanine is metabolically a precursor of xanthine and is thus indirectly a source of uric acid. |