lathyrogen, n. Med.
(ˈlæθɪrədʒən)
[f. lathyrism n. + -ogen.]
A substance which causes lathyrism.
| 1962 Laboratory Investigation XI. 697/1 It has not been proven whether the lesions result from the direct action of the lathyrogen on the cartilage or from the action of some metabolic product of the lathyrogenic agent. 1972 Science 5 May 512/2 Most common among toxic substances are the enzyme inhibitors... Physiological irritants might be the next most common category. These include..the lathyrogens, which disrupt collagen structure and occur in peas. 1978 Nature 11 May 151/2 Direct evidence that the structure of collagen influences morphogenetic events is provided by studies in vivo with lathyrogens such as β-amino-propionitrile, which interfere with the crosslinking of collagen by inhibiting the action of the enzyme lysyl oxidase. |
So lathyroˈgenic a.
| 1958 Proc. Soc. Exper. Biol. & Med. XCVII. 114/1 Methyleneaminoacetonitrile has also been reported to be strongly lathyrogenic. 1983 Exper. Neurol. LXXIX. 102 The first question..is whether the fibrogenic components of the peripheral nerve will be exposed to the lathyrogenic effects of β-APN when it is topically applied. |