labilize, v. Chem. and Biochem.
(ˈleɪbɪlaɪz)
[f. labile a. + -ize.]
trans. To render labile (esp. a chemical bond). So ˈlabilizing ppl. a. and vbl. n.
| 1903 Nature 26 Feb. 385/2 The rôle of the oxygen must have been that of a labilising agent. 1938 Jrnl. Biol. Chem. CXXV. 1 These and other polar groups..may conceivably labilize adjacent carbon-bound hydrogen atoms. 1957 New Biol. XXIII. 77 Proteins could also have become radioactive by an exchange reaction in which two peptide bonds in the chain of a protein are labilized, allowing an amino acid held at this point to be exchanged with another molecule of the same amino acid present in the surrounding medium. 1962 Biochem. Pharmacol. IX. 113 Stabilization disappears and is replaced by a labilizing influence. 1972 European Jrnl. Biochem. XXVI. 540/1 Free lysosome enzymes can labilize lysosomal membrane. 1973 Chem. Soc. Rev. II. 177 The factor responsible for a high labilizing ability depends on this mechanism. |
Hence ˌlabiliˈzation, the process of rendering or becoming labile; ˈlabilizer, a labilizing agent.
| 1938 Jrnl. Biol. Chem. CXXV. 19 Stekol and Hamill..have claimed that proteolytic enzymes can carry out such a labilization. 1956 Radiation Res. V. 263 The increased susceptibility of X-irradiated DNP to the action of trypsin is not inconsistent with the concept of a labilization of the DNA-to-protein salt-like secondary linkages. 1965 Dissertation Abstr. XXV. 4355/2 It is concluded that the labilization of the carboxyl carbon of glycine is a discrete reaction which can be measured independently of reactions related to further metabolism of the α-carbon. 1967 Pike & Brown Nutrition vii. 145 Other labilizers of the lysosomal membrane are ultraviolet light and ionizing radiation. 1974 Nature 13 Dec. 579/1 The labilisation of the ligand trans to an oxo group is a well known effect. |