sideroblast Med.
(ˈsɪdərəʊblɑːst, -æ-)
[f. sidero-1 + -blast.]
A normoblast containing one or more granules of ferritin.
| 1954 E. Kaplan et al. in Blood IX. 204 For the purpose of this report these cells were designated as ‘sideroblasts’ in analogy to the term siderocyte already generally accepted for erythrocytes with iron-staining inclusions. Ibid. 212 The term sideroblast was proposed for normoblasts with nonstaining inclusions. 1962 Bothwell & Finch Iron Metabolism 289 Sideroblasts are absent in iron-deficiency anemia. 1972 Passmore & Robson Compan. Med. Stud. III. xxi. 29/2 Ring sideroblasts were first observed in 1949 in guinea-pigs suffering from lead poisoning. They were first described in man in 1953. 1976 Lancet 18 Dec. 1364/1 The patient's bone-marrow exhibited a variable number of normal sideroblasts ranging from 20 to 70%. |
Hence sideroˈblastic a., of, pertaining to, or characterized by the presence of sideroblasts; esp. in sideroblastic anæmia.
| 1956 Blood XI. 250 (heading) Chronic refractory anemia with sideroblastic bone marrow. 1972 Nature 10 Mar. 73/1 A similar although lesser degree of defective synthesis is seen in two other conditions due to haem deficiency, namely sideroblastic anaemia, and iron deficiency anaemia. 1977 Blood L. 165/2 Sideroblastic anemia..is a heterogeneous group of disorders with different basic biochemical abnormalities. |