pyrazinamide Pharm.
(paɪər-, pɪrəˈzɪnəmaɪd)
[f. pyrazine + amide.]
A white crystalline powder, pyrazine-2-carboxamide, CH:N·CH:CH·N:C·CONH2, which is used in the treatment of tuberculosis, usu. in conjunction with other drugs.
| 1952 Amer. Rev. Tuberculosis LXV. 515 The antituberculous activity of pyrazinamide..in mice lies between that of streptomycin and that of PAS. 1961 Lancet 2 Sept. 533/2 With 1 g. of streptomycin daily on six days a week..and 1–1·5 g. of pyrazinamide in a single daily dose by mouth, 32..of the 57 patients..attained bacteriological quiescence by the end of the year. 1974 R. M. Kirk et al. Surgery ii. 29/2 Ethionamide, pyrazinamide, viomyocin and capreomycin may be used in the treatment of tuberculosis when it proves resistant to the usual combination of streptomycin, INAH, and PAS. |