ˈmissense, a. Biol.
[mis-1 4.]
Causing or involving the insertion of a different amino-acid at a particular point in a polypeptide or protein molecule from that which is usual.
| 1961 Levinthal & Davison in Ann. Rev. Biochem. XXX. 651 An alteration in any base pair by a mutagen raises the possibility of a class of so-called nonsense mutations, as well as a class of missense mutations... A missense mutation in this context is one which causes a substitution of one amino acid for another at a particular position in the protein. 1974 Nature 2 Aug. 412/1 The missense mutation trpA36 results in a Gly (GGA)→Arg (AGA) amino acid substitution at position 211 of the tryptophan synthetase A protein. Ibid. 413/1 The anticodons of the suppressor tRNAs are complementary to the missense codons suppressed by these tRNAs. |